Written by Rachel Nall, RN, BSN | Published on October 3, 2014
Medically Reviewed by Susan J. Bliss, RPh, MBA on October 3, 2014

What Is Complera?

Brand Name: Complera
Generic Names: Emtricitabine/Rilpivirine/Tenofovir Disoproxil Fumarate (FTC/RPV/TDF)


Complera is a combination drug used to reduce the levels of the HIV virus in the bloodstream and improve the functioning of the immune system. Complera includes three drugs in one tablet. This helps to simplify treatment in appropriate patients. The drug is commonly prescribed for people who have never taken an HIV medication before. It’s also given to some patients who have been previously and successfully treated for at least six months, with no history of treatment failure. To take Complera, the patient’s viral load must be less than 100,000 copies per milliliter (mL).

Read the FDA description of Complera.

What Does Complera Do?

Complera is not a cure for HIV. It reduces the ability of the HIV virus to multiply in the body. This results in an increase the number of CD4+ T cells in the blood. Adequate numbers of CD4+ cells are required by the body to maintain a healthy immune system. 

What Are the Typical Doses?

Complera is approved to treat adults with HIV. The adult dose of Complera is one tablet daily. The one tablet contains emtricitabine 200 milligrams (mg), rilpivirine 25 mg, and tenofovir disoproxil fumarate 300 mg. Take Complera with a full meal for the best absorption. 

If you miss a dose of Complera and the time is less than 12 hours from when you typically take it, you can take the missed dose with a meal. Resume your normal medication schedule. However, if it’s longer than 12 hours from when you take it, take your next dose. Do not double up on doses or take Complera with other medications used to treat HIV. 

When rifabutin (for tuberculosis) is taken with complera, an additional 25 mg tablet of rilpivirine should be added.

Since Complera is a fixed (single strength) combination product, it’s not recommended for patients with kidney disease who require reduced doses. 

Do not stop taking or change the dosage of Complera without first discussing your treatment with your doctor.

This information is a summary. Before starting this medication, discuss questions with your healthcare provider and make sure you understand dosage instructions.

What Should I Tell My Doctor Before Starting Complera?

Tell your doctor before taking Complera if you:

  • are breastfeeding or planning on breastfeeding, as the HIV virus and Complera can pass through breast milk
  • are pregnant or are planning on becoming pregnant
  • have bone problems
  • have kidney issues
  • have liver issues, such as hepatitis B or C or abnormal liver enzymes
  • have mental health conditions, such as bipolar disorder or depression

What Medications May Interact with Complera?

Always tell your physician about any prescription medications or herbal remedies you are taking. And tell your doctor if you have taken other medications for HIV in the past. Complera can interact with numerous medications and herbal remedies. Provide your physician with a complete medication list before starting to take Complera.

Medications used for several conditions interact with Complera and may require dose adjustments or should not be used at the same time.  The following list of health conditions includes common medications used to treat them.  If you are taking any of these medications, ask your physician or pharmacist if you should take them with Complera. 

  • For infections: erythromycin, clarithromycin and aminoglycosides (usually used in the hospital) and antifungal drugs (ketoconazole, for example) may all interact with Complera. 
  • For seizures: carbamazepine (for example, Tegretrol), oxcarbazepine (for example, Trileptal), phenobarbitol (for example, Luminal), or phenytoin (for example, Dilantin)
  • For stomach or intestinal conditions: proton pump inhibitors (PPIs) including esomeprazole (for example, Nexium), lansoprazole (for example, Prevacid), omeprazole (for example, Prilosec), or pantoprazole sodium (Protonix). These reduce the blood level of Complera and should not be taken with it. Cisapride taken with Complera increases the risk of heart arrhythmias and they should not be taken together. 
  • For tuberculosis: rifabutin (Mycobutin), rifampin (Rifadin), or rifapentine (Priftin)
  • Nonsteroidal anti-inflammatory medications (ibuprofen, naproxen and others) and the steroid dexamethasone can also affect blood levels of Complera. Discuss with your physician before taking any of these drugs while taking Complera.
  • St. John’s wort should not be taken while you are also taking Complera.

If you take antacids (calcium, magnesium or aluminum containing products) tell your physician, as they could affect absorption. Antacids and calcium may be taken, when correctly separated from doses of Complera. 

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