Major Depressive Disorder

Major Depressive Disorder

Major depressive disorder (MDD) is a debilitating disease that can seriously affect a person's health, wellbeing, and life. People with major depression experience extended periods of sadness, emptiness, and despair, and they are often unable to enjoy activities that they once found pleasurable. MDD can cause problems with a person’s diet, sleep, work life, and ability to connect with others.

Although many people use the word "depression" to describe this mood disorder, medical professionals prefer to use the term "major depressive disorder" or "major depression," both of which are more clinically precise, describing a specific medical condition, as opposed to a general group of behaviors. Learn more about the symptoms of MDD, treatments, and medications.

Depression Stories: Hear from Real Patients

Real patients talk about their experiences living with and treating major depressive disorder (MDD).

Depression Warning Signs

Learn the symptoms of untreated or unresolved depression.

Combination Therapies for Depression

New research is showing that combining antidepressants with medications for other mood disorders can be effective in helping patients achieve a higher degree of remission.

Depression Medications and Side Effects

Learn about the most frequently prescribed antidepressant medicines and their most common side effects.

A Self-Help Guide to Dealing with Depression

Learn about alternative therapies and get tips for dealing with depression.

Recognizing Unresolved Symptoms of Depression

Learn the risks and warning signed associated with unresolved depression, including topics to bring up with your doctor.

Is Your Depression Treatment Working?

If you’re treating for major depressive disorder (MDD), learn about residual symptoms, risk factors, and questions you should be asking your doctor.

The Dangers of Abruptly Stopping Antidepressants

There any many risks associated with stopping antidepressant medication without first consulting your doctor.