OCTYPE html> < a property="fb:app_id" content="1529595680591919"/> < >Crying Cat Syndrome (Cri-du-Chat) > s yndrome, also called Cri-du-chat or 5P syndrome, is a genetic condition where your baby is born with a deletion on the short arm of chromosome 5. The condition is rare and occurs in only about 1 in 20,000 to 1 in 50,000 newborns. 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left sticky box border --></div> <div class="box-right-border-persist"><!-- right sticky box border --></div> </div><!-- box-sticky --> </div> </div> </div> </div><!-- header --><div class="hl" id="hl"> <div class="container c"> <div class="hl-loading-mask"> <div aria-hidden="true" class="hl-loading-mask-spinner hl-icon-spinner spinner--steps"></div> </div> <div class="overlay-simple overlay-sharebar" id="overlaySharebar"> <div class="overlay-content"> </div> <div class="overlay-footer"> <div class="overlay-close">Cancel</div> </div> </div> <header class="hl-title-area"> <div class="article-header" itemprop="headline"> <h1>Crying Cat Syndrome (Cri-du-Chat)</h1> </div> <p class="attribution" id="byline"> Written by Rose Kivi | Published on <meta content="2012-08-07" itemprop="datePublished"/>August 7, 2012<br/>Medically Reviewed by <a href="http://www.healthline.com/health/medical-board">George Krucik, MD</a> </p> <div class="hl-widget-sharebar c"></div> <div 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d.createElement(s); js.id = id; js.src = "//connect.facebook.net/en_US/sdk.js"; fjs.parentNode.insertBefore(js, fjs); }(document, 'script', 'facebook-jssdk'));</script> <div class="container-article" itemscope="" itemtype="http://schema.org/Article"> <article class="hl-article-toc"> <h2 class="content_head" id="TOC_TITLE_HDR_1"><a name="Overview"></a>What is Crying Cat Syndrome? </h2><div class="content_body" id="TOC_TITLE_1"> <p>Crying cat syndrome, also called Cri-du-chat or 5P syndrome, is a genetic condition where your baby is born with a deletion on the short arm of chromosome 5. The condition is rare and occurs in only about 1 in 20,000 to 1 in 50,000 newborns. Yet, it is one of the most common syndromes caused by chromosomal deletion.</p> <p>Like its name implies, the syndrome makes infants produce a high-pitched cry similar to a cat. (“Cri-du-chat” means “cry of the cat” in French.) The cry is caused by an abnormal development of your child’s larynx due to the chromosome deletion. The syndrome is more noticeable as your child ages, but becomes difficult to diagnose past the age of two. </p> <p>Crying cat also carries many disabilities and abnormalities. A small portion of infants with crying cat syndrome is born with serious organ defects or other life threatening complications that can result in death. Most fatal complications occur before a child’s first birthday. </p> <p>Children who reach the age of 1, though, generally have a normal life expectancy. Still, your child will most likely have lifelong physical and/or development complications, and these will depend on the severity of the syndrome. </p> <p>The good news: about one-half of children with crying cat syndrome learn enough words to communicate, and most grown up to be happy, friendly, and sociable.</p> </div> <h2 class="content_head" id="TOC_TITLE_HDR_2"><a name="Causes"></a>What Causes Crying Cat Syndrome? </h2> <div class="content_body" id="TOC_TITLE_2"> <p>The exact reason for the chromosome 5 depletion is unknown. In most cases, though, the chromosome break happens while the parent’s sperm or egg cell is still developing. When fertilization occurs, your child develops the syndrome. About 80 percent of affected children experience chromosome deletion that comes from their father’s sperm. </p> <p>This break is usually so rare it is unlikely to happen again should you and your spouse have another child. However, if you have a family history of crying cat syndrome, your unborn child has a slightly increased risk of being born with the condition. Approximately 10 percent of cases are inherited from a parent.</p> </div> <h2 class="content_head" id="TOC_TITLE_HDR_3"><a name="Symptoms"></a>What are the Symptoms of Crying Cat Syndrome? </h2> <div class="content_body" id="TOC_TITLE_3"> <p>The severity of your child’s symptoms depends on how much genetic information is missing from chromosome 5. Some symptoms are severe while others are so minor they may go undiagnosed. The cat-like cry, which is the most common symptom, becomes less noticeable over time. </p> <h3>Physical Signs</h3> <p>Children born with crying cat are commonly small at birth. They may also experience respiratory difficulties. Besides the namesake cat cry, other distinctive physical features include:</p> <ul type="disc"> <li>small chin</li> <li>unusually round face</li> <li>small bridge of the nose</li> <li>folds of skin over their eyes</li> <li>abnormally wide-set eyes (ocular or orbital hypertelorism) </li> </ul> <ul> <li>abnormally shaped or low-set ears</li> <li>a small jaw (<A id="hllink133" class="hllink hllink-auto" href="http://www.healthline.com/health/micrognathia">micrognathia</A>)</li> <li>partial webbing of the fingers or <A id="hllink140" class="hllink hllink-auto" href="http://www.healthline.com/health/webbing-of-the-fingers-or-toes">toes</A></li> <li>single line on the palm of the hand</li> <li>an inguinal hernia (a protrusion of organs through a weak area or tear in the abdominal wall)</li> </ul> <h3>Other Signs </h3> <p>Internal problems are common too. Children can have <A id="hllink159" class="hllink hllink-auto" href="http://www.healthline.com/human-body-maps/skeletal-system">skeletal</A> problems like <A id="hllink161" class="hllink hllink-auto" href="http://www.healthline.com/health/scoliosis">scoliosis</A> (abnormal curvature of the spine), heart or other organ defects, poor muscle tone (during infancy and childhood), or hearing and vision difficulties. As they grow, they often experience trouble talking, walking, and feeding, and can have behavioral problems, such as <A id="hllink173" class="hllink hllink-auto" href="http://www.healthline.com/health/hyperactivity">hyperactivity</A> or aggression. </p><p> Children also may suffer from severe mental retardation (the syndrome accounts for about 1 percent of those with mental retardation). However, if your child does not experience defects with major organs or other critical medical conditions, their life expectancy is average. </p> </div> <h2 class="content_head" id="TOC_TITLE_HDR_4"><a name="Diagnosis"></a>How is Crying Cat Syndrome Diagnosed? </h2> <div class="content_body" id="TOC_TITLE_4"> <p>Doctors usually diagnose crying cat syndrome at birth, based on physical abnormalities and displayed symptoms. Your doctor may also perform an X-ray on your child’s <A id="hllink208" class="hllink hllink-auto" href="http://www.healthline.com/human-body-maps/head">head</A> to detect abnormalities in the base of the skull </p> <p>To confirm a diagnosis, a chromosome test often will be performed. A specialized technique called a FISH analysis may be used to help detect small deletions. If you have a family history of crying cat, your doctor may suggest a chromosome analysis or genetic testing while your child is still in the womb. The doctor can either test a small sample of tissue from outside the sac where your child develops, (known as CVS or chorionic villus sampling) or they may test a sample of amniotic fluid.</p> </div> <h2 class="content_head" id="TOC_TITLE_HDR_5"><a name="Treatment"></a>How is Crying Cat Syndrome Treated? </h2> <div class="content_body" id="TOC_TITLE_5"> <p>There is no specific treatment for crying cat syndrome. You can help manage the symptoms with physical therapy, language and motor skill therapy, and education intervention. </p> </div> <h2 class="content_head" id="TOC_TITLE_HDR_6"><a name="Prevention"></a>Can You Prevent Crying Cat Syndrome? </h2> <div class="content_body" id="TOC_TITLE_6"> <p>There is no known way to prevent crying cat syndrome. If you have a family history of the syndrome, even if you don’t display symptoms, you still may be a carrier, and should consider a genetic test. </p> <p>You also may carry a type of defect called a balanced translocation, which is a defect in the chromosome that does not result in the loss of genetic material. However, if you pass the defective chromosome to your child, it may become unbalanced, which results in the loss of genetic material and can cause the syndrome.</p> </div></article> <div class="span12 box-share-help-feedback"> <div class="span5"> <div class="box-article-helpful"> <div class="box-helpful-question"> Was this article helpful? <span class="helpful-option-yes">Yes</span> <span class="helpful-option-no">No</span> </div> <div class="box-helpful-confirmation"></div> </div> </div> <div class="span3"> <div class="box-link-feedback"> <span class="icon-email"></span> <a class="link-feedback" href="#feedbackOverlay" id="feedbackLink" rel="#feedbackOverlay">Feedback?</a> </div> <div class="overlay-simple overlay-feedback" id="feedbackOverlay"> <div class="overlay-content"> <div class="box-form-feedback" id="feedbackformdiv"> <form action="/v2/widgetemail" id="feedbackform"> <input name="to" type="hidden" value="hrl"></input> <input id="urlfield" name="urlfield" type="hidden" value=""></input> <h2>Send us your feedback</h2> <p class="box-message">We are unable to respond directly to questions, but your feedback is greatly appreciated, and will be taken into account in our ongoing review of our Health Reference Library.<br/></p> <p> <label>Your Name:</label><br/> <input class="field-name" id="nametext" name="nametext" placeholder="Name Here" type="text"></input> <span class="box-msg-error" id="box-msg-name"><span class="icon-error">✖</span> <span id="errorMsgName">Please enter your name</span></span> </p> <p> <label>Your Email:</label><br/> <input class="field-email-address" id="feedbackemail" name="emailaddress" placeholder="name@example.com" type="email"></input> <span class="box-msg-error" id="box-msg-email"><span class="icon-error">✖</span> <span id="errorMsgEmail">Please enter your email</span></span> </p> <p> <input id="copy" name="copy" type="checkbox"></input> <label>Send me a copy</label> </p> <p class="box-textarea"> <textarea class="field-message" cols="60" id="feedbacktextarea" name="messagetext" rows="4"></textarea> </p> <div class="textarea-char-count" id="charcount">0</div> <p class="box-buttons"> <button class="btn-cancel" name="feedbackcancelbutton" type="button">Cancel</button> <button class="btn-send-msg">Send Message</button> <span class="box-loading"><img alt="" src="http://www.healthline.com/resources/base/images/ajax-loader.gif"/></span> </p> </form> <p class="box-privacy"><span class="icon-lock"></span> Email addresses will not be shared with 3rd parties. 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(n.d.). <em>Welcome to the 5P- Society - <A id="hllink375" class="hllink hllink-auto" href="http://www.healthline.com/health/alcohol-addiction-support-groups">Support Group</A> for 5 P Minus Society - Children with Cri du chat Syndrome</em>. Retrieved April 24, 2012, from <a href="http://www.fivepminus.org/about.htm">http://www.fivepminus.org/about.htm</a> </li> <li>Cri-du-chat syndrome - Genetics Home Reference. (n.d.). <em>U.S. National Library of Medicine, Genetics Home Reference - Your guide to understanding genetic conditions</em>. Retrieved April 24, 2012, from <a href="http://ghr.nlm.nih.gov/condition/cri-du-chat-syndrome">http://ghr.nlm.nih.gov/condition/cri-du-chat-syndrome</a> </li> <li>Learning About Cri du Chat. (n.d.). <em>National Human Genome Research Institute (NHGRI) - Homepage</em>. Retrieved April 24, 2012, from <a href="http://www.genome.gov/19517558">http://www.genome.gov/19517558</a> </li> <li>Mainardi, P. C. (2006). Cri du chat syndrome. <em>Orphanet Journal of Rare Diseases</em>, <em>1:33</em>. 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promoTitle = "Trending Now"; partnerId = 28; adRefresh = true; if ( $( ".hl-sponsor-disclaimer" ).length ) { sponsorDisclaimerOffset = 78; } cfg = { promoTitle: promoTitle, partnerId: partnerId, contentPromoOffset: 70, sponsorDisclaimerOffset: sponsorDisclaimerOffset, adRefresh: adRefresh, mr1RefreshTime: mr1RefreshTime, isLargeLandscapeImage: isLargeLandscapeImage } WidgetTabNavigation.initialize(cfg); }); </script> <script> require([ 'jquery' ], function( $ ){ // activate toggle for hide/show FB comments $(window).load(function() { if( $('.fb-view-comments-bar').length ) { $('.fb-view-comments-bar').click(function() { $('.fb-view-comments-bar').toggleClass( 'open' ); if( $('.fb-view-comments-bar').hasClass( 'open' ) ) { $('.fb-view-comments-bar span.fb-view-comments-arrow').removeClass( "hl-icon-right-solid-arrow" ).addClass('hl-icon-down-arrow'); $('#fb-view-count').hide(); } else { $('.fb-view-comments-bar span.fb-view-comments-arrow').removeClass( "hl-icon-down-arrow" ).addClass('hl-icon-right-solid-arrow'); $('#fb-view-count').show(); } if($('#fb-view-count').html() == ' ()') $('#fb-view-count').hide(); }); } }); }); </script> <script> require(["jquery","base/overlay","base/feedback"],function($,AppOverlay){ var onBeforeLoadFunc = function() { $('.hl-main-content').css('z-index','auto'); $('#feedbackformdiv').show(); }; var cfgOverlay = { selectorValue: 'feedbackOverlay', maskColor: '#555555', maskLoadSpeed: 200, maskOpacity: 0.5, maskZindex: 9999999, top: "center", left: "center", close: ".overlay-close", onBeforeLoad: onBeforeLoadFunc }; AppOverlay.initialize(cfgOverlay); }); </script> <script> require(['jquery', 'base/content-promotion-widget'],function($, AppContentPromotion){ var config = { contentPromotionParam: '', platformPageType: 'articleTOC' }; AppContentPromotion.initialize(config); }); </script> <script> u_microsoft_adunit_channelids = "" microsoft_adunit_channelids = ""; document.write('<input id="msftChannelIds1" name="msftChannelIds1" type="hidden" value="'+microsoft_adunit_channelids+'">'); require(['jquery',"base/dfpmanager","base/responsive-ads","matchmedia"],function($,AppDfpmanager,AppResponsiveAds){ // determine if mr1 ad is shown on page load var isAdOnPageLoad = true; var breakpointsToHideAd = []; var breakpointsToHideAdByPageType = []; breakpointsToHideAdByPageType = ['768','600','480','320']; isAdOnPageLoad = AppResponsiveAds.getShowAdOnPageLoad("MR1",breakpointsToHideAd,breakpointsToHideAdByPageType); var adSize = '300x250,300x600'; if(matchMedia('only screen and (max-width: 600px)').matches) { adSize = '300x50,300x250'; } var cfgDfpManager = { isAdOnPageLoad: isAdOnPageLoad, adshost : 'http://ads.healthline.com', adSize: adSize, dfpAdSite : 'hn.us.hl.lc.x.x.x', btk1 : '', btk2 : '', kw : 'birthdefects,crying_cat_syndrome_causes,4979483', k1 : 'birthdefects', k2 : 'infanthealth', k3 : 'health', pos : 'mr1', ugc : 'false', ac : '', uac : '', akh : 'Crying Cat Syndrome Cri du Chat ', aks : '5000', env : '', msiteID : '', adTagPageUrl : encodeURIComponent('/health/cri-du-chat-syndrome'), yeildex : 'true', targetsrc : '' }; var mr1timeout = setTimeout(function() { AppDfpmanager.mr1IframeInit(cfgDfpManager); }, 300); }); </script> <script> require(["jquery","base/dfpmanager","base/responsive-ads","matchmedia"],function($,AppDfpmanager,AppResponsiveAds){ $(function() { // determine if mr2 ad is shown on page load var isAdOnPageLoad = true; var breakpointsToHideAd = []; var breakpointsToHideAdByPageType = []; breakpointsToHideAd = ['997','768','600','480','320']; var isAdOnPageLoad = AppResponsiveAds.getShowAdOnPageLoad("MR2",breakpointsToHideAd,breakpointsToHideAdByPageType); var cfgDfpManager = { isAdOnPageLoad: isAdOnPageLoad, adshost : 'http://ads.healthline.com', dfpAdSite : 'hn.us.hl.lc.x.x.x', btk1 : '', btk2 : '', kw : 'birthdefects,crying_cat_syndrome_causes,4979483', k1 : 'birthdefects', k2 : 'infanthealth', k3 : 'health', pos : 'mr2', ugc : 'false', ac : '', uac : '', env : '', msiteID : '', adTagPageUrl : encodeURIComponent('/health/cri-du-chat-syndrome'), yeildex : 'true' , targetsrc : '' }; AppDfpmanager.mr2IframeInit(cfgDfpManager); }); // dom ready }); </script> <script> var isWslAdDisplayed = false; // check if adPositionsToHide from Config file is not empty for current partner // if true, then get values // then compare values to this page adPositionsToHide // - add new ones from config file to this page var configAdPositionsToHide; var addAdPosition = true; var pageAdPositionsToHide = ['wsr']; // page type specific ads to hide if( !isWslAdDisplayed ) { pageAdPositionsToHide.push('wsl'); } var rightRailNotSticky = false, isBackToTop = false; rightRailNotSticky = false; require([ 'base/article-toc', 'base/article-common' ], function( AppArticleToc, AppArticleTocCommon ){ AppArticleToc.initialize({ isWslAdDisplayed: isWslAdDisplayed, isArticleHelpful: false, partnerId: 28, titleAreaTop: '60px', tabNavigationTop: '85px', isBackToTop: isBackToTop, tabNavMaxWidth: '1008px', rightRailNotSticky: rightRailNotSticky, tabArticleWidth: 978, stickyTitlePaddingAuto: false, isFbCommentsOn: false, rightRailNotSticky: rightRailNotSticky }); AppArticleTocCommon.initialize(); }); var isMsiteId = false; var isMoveMr2 = true; require([ "base/rwd/article-toc" ], function( AppArticleTocRwd ){ AppArticleTocRwd.initialize({ isMsiteId: isMsiteId, adRBTimeDelay: 300, isMoveMr2: isMoveMr2 }); }); require([ "base/rwd/sharebar-mobile" ], function( AppSharebarMobile ){ AppSharebarMobile.initialize(); }); </script> <script> require(['jquery',"base/dfpmanager","base/responsive-ads","matchmedia"],function($,AppDfpmanager,AppResponsiveAds){ $(function() { // determine if pb ad is shown on page load var isAdOnPageLoad = true; var breakpointsToHideAd = []; var breakpointsToHideAdByPageType = []; breakpointsToHideAd = ['600','480','320']; var isAdOnPageLoad = AppResponsiveAds.getShowAdOnPageLoad("PB",breakpointsToHideAd,breakpointsToHideAdByPageType); var cfgDfpManager = { isAdOnPageLoad: isAdOnPageLoad, adshost : 'http://ads.healthline.com', logged_in : 'false', dfpAdSite : 'hn.us.hl.lc.x.x.x', btk1 : '', btk2 : '', kw : 'birthdefects,crying_cat_syndrome_causes,4979483', k1 : 'birthdefects', k2 : 'infanthealth', k3 : 'health', pos : 'lb', ugc : 'false', ac : '', uac : '', akh : '', aks : '5000', env : '', msiteID : '', adTagPageUrl : encodeURIComponent('/health/cri-du-chat-syndrome'), partner : 'healthline', pg_dart_site : 'hn.us.hl.lc.x.x.x', pg_dart_zone : 'birthdefects', pg_k2 : 'infanthealth', pHLID : '4979483', HLID : '4979483|4979487|4979482', visit_type : 'HCviewer', yeildex : 'true', targetsrc : '' }; var pbtimeout = setTimeout(function() { AppDfpmanager.pbIframeInit(cfgDfpManager); }, 300); }); // dom ready }); </script> <script> var HL_adBlankMonitor = function(cfg) { if(cfg.adBlankCodes.length > 0) { for(var i = 0; i < cfg.adBlankCodes.length; i++) { if (typeof HL_ga_sendTrackEvent === 'function') { HL_ga_sendTrackEvent({ gaEventCategory : 'Ad Display', gaEventAction : 'Blank Ad', gaEventLabel : 'adBlankCode=' + cfg.adBlankCodes[i] + '&adspot=' + cfg.adPosition + '&pageUrl=' + window.location.pathname }); } } } }; require(["base/util/visit-tracker"],function(AppVisitTracker){ AppVisitTracker.initialize(); }); </script> <script> require([ 'healthline/newsletter-signup' ], function( newsletterSignup ){ newsletterSignup.setConfig({ newsletterHost: 'newsletter.healthline.com' }); }); </script> <script> /* load module */ require(["healthline/footer"]); </script> </meta>