Atherosclerosis is a narrowing of the arteries caused by a buildup of plaque. It’s also called arteriosclerosis or hardening of the arteries. Arteries are the blood vessels that carry oxygen and nutrients from your heart to the rest of your body.

As you get older, fat and cholesterol can collect in your arteries and form plaque. The buildup of plaque makes it difficult for blood to flow through your arteries. This buildup may occur in any artery in your body and can result in a shortage of blood and oxygen in various tissues of your body. Pieces of plaque can also break off, causing a blood clot. Atherosclerosis can lead to heart attack, stroke, and heart failure if left untreated.

Atherosclerosis is a fairly common problem associated with aging. This condition can be prevented, and many successful treatment options exist.

What Are the Types of Atherosclerosis?

Atherosclerosis occurs when fat, cholesterol, and calcium harden in your arteries. Atherosclerosis can occur in an artery anywhere in your body, including your heart, legs, and kidneys.

Other types of atherosclerosis are:

Coronary Artery Disease

Coronary artery disease occurs when the coronary arteries of your heart become hard. The coronary arteries are blood vessels that provide your heart’s muscle tissue with oxygen and blood. Plaque prevents blood flow to the heart.

Carotid Artery Disease

The carotid arteries are found in your neck and supply blood to your brain. These arteries may be compromised if plaque builds up in their walls. The lack of circulation may reduce how much blood and oxygen reaches your brain’s tissue and cells.

Peripheral Artery Disease

Your legs, arms, and lower body depend on your arteries to supply blood and oxygen to their tissues. Hardened arteries can cause circulation problems in these areas of the body.

Kidney Disease

The renal arteries supply blood to your kidneys. Kidneys filter waste products and extra water from your blood. Atherosclerosis of these arteries may lead to kidney failure.

What Causes Atherosclerosis?

Plaque buildup and subsequent hardening of the arteries restricts blood flow in the arteries, preventing your organs and tissues from getting the oxygenated blood they need to function.

The following are common causes of hardening of the arteries:

High Cholesterol

Cholesterol is a waxy, yellow substance that’s found naturally in your body and also in certain foods you eat. This substance can increase in your blood and clog your arteries. It becomes a hard plaque that restricts or blocks blood circulation to your heart and other organs.


Eating foods high in fat may also lead to plaque buildup.


As you age, your heart and blood vessels work harder to pump and receive blood. Your arteries may weaken and become less elastic, making them more susceptible to plaque buildup.

Who Is at Risk for Atherosclerosis?

Many factors place you at risk for atherosclerosis. Some risks can be prevented, while others cannot.

Family History

If atherosclerosis runs in your family, you may be at risk for hardening of the arteries. This condition as well as other heart-related problems may be inherited.

Lack of Exercise

Regular exercise is good for your heart. It keeps your heart muscle strong and encourages oxygen and blood flow throughout your body. Living a sedentary lifestyle increases your risk for a host of medical conditions, including heart disease.


Eating foods high in fats and cholesterol raises your risk for atherosclerosis.

High Blood Pressure

High blood pressure can damage your blood vessels by making them weak in some areas. Cholesterol and other substances in your blood may reduce the flexibility of your arteries over time.


Smoking tobacco products can damage your blood vessels and heart.


People with diabetes have a much higher incidence of coronary artery disease.

What Are the Symptoms of Atherosclerosis?

Most symptoms of atherosclerosis don’t show until a blockage occurs. Common symptoms include:

  • chest pain or angina
  • pain in your leg, arm, and anywhere else that has a blocked artery
  • shortness of breath
  • fatigue
  • confusion, which occurs if the blockage affects circulation to your brain
  • muscle weakness in your legs from lack of circulation

It’s also important to know the symptoms of heart attack and stroke. Both of these problems can be caused by atherosclerosis and require immediate medical attention. The symptoms of a heart attack include:

  • chest pain or discomfort
  • pain in the shoulders, back, neck, arms, and jaw
  • abdominal pain
  • shortness of breath
  • perspiration
  • lightheadedness
  • nausea or vomiting
  • a sense of impending doom

The symptoms of stroke include:

  • weakness or numbness in the face or limbs
  • trouble speaking
  • trouble understanding speech
  • vision problems
  • loss of balance
  • sudden, severe headache

Call 911 and get to a hospital's emergency room as soon as possible if you experience symptoms of a heart attack or stroke. 

How Is Atherosclerosis Diagnosed?

Your doctor will perform a physical exam if you have symptoms of atherosclerosis. They’ll check for:

  • a weakened pulse
  • an aneurysm, which is an abnormal bulging or widening of an artery due to weakness
  • slow wound healing, which indicates a restricted blood flow

A heart specialist called a cardiologist may listen to your heart to see if you have any abnormal sounds. They’ll be listening for a whooshing noise, which indicates that an artery is blocked. Your doctor will order more tests if they think you may have atherosclerosis. These tests can include:

  • a blood test to check your cholesterol levels
  • a Doppler ultrasound, which uses sound waves to create a picture of the artery that shows if there’s a blockage
  • ankle-brachial index test, which looks for a blockage in your arms or legs by comparing the blood pressure in each limb
  • magnetic resonance arteriography (MRA) or computed tomography angiography (CTA) to create pictures of the large arteries in your body
  • cardiac angiogram, which requires an injection of a radioactive dye that can be seen on X-rays to create a picture of the arteries in your heart
  • an electrocardiogram (EKG), which measures the electrical activity in your heart to look for any areas of decreased blood flow
  • a stress test, or exercise tolerance test, which monitors your heart rate and blood pressure while you exercise on a treadmill or stationary bicycle

How Is Atherosclerosis Treated?

Treatment involves changing your current lifestyle to one that limits the amount of fat and cholesterol you consume. You may need to exercise more to improve the health of your heart and blood vessels.

You may also need additional medical treatments, such as:


Medications can help prevent atherosclerosis from worsening. Medications include:

  • cholesterol-lowering medications, including statins and fibric acid derivatives
  • antiplatelet drugs and anticoagulants, such as aspirin, to prevent blood from clotting and clogging your arteries
  • beta blockers or calcium channel blockers to lower your blood pressure
  • diuretics, or water pills, to help lower your blood pressure
  • angiotensin converting enzyme (ACE) inhibitors, which help prevent narrowing of your arteries


In some cases, surgery may be necessary if symptoms are especially severe, or if muscle or skin tissue are endangered. Possible surgeries for treating atherosclerosis include:

  • bypass surgery, which involves using a vessel from somewhere else in your body or a synthetic tube to divert blood around your blocked or narrowed artery
  • thrombolytic therapy, which involves dissolving a blood clot by injecting a drug into your affected artery
  • angioplasty, which involves using a thin, flexible tube called a catheter and a balloon to expand your artery
  • endarterectomy, which involves surgically removing fatty deposits from your artery
  • atherectomy, which involves removing plaque from your arteries by using a catheter with a sharp blade at one end

What to Expect in the Long Term

With treatment, you may see improvement in your health, but this may take time. The success of your treatment will depend on the severity of your condition, how promptly it was treated, and whether other organs were affected. Hardening of the arteries cannot be reversed, but treating the underlying cause and making healthy lifestyle and dietary changes can help slow down the process or prevent it from getting worse. 

You should work closely with your doctor to make the appropriate lifestyle changes. You’ll also need to take the proper medications to control your condition and avoid complications. The complications of atherosclerosis include:

  • heart failure
  • heart disease
  • heart attack
  • abnormal heart rhythm
  • stroke
  • peripheral artery disease, which reduces blood flow to your arms and legs
  • kidney failure
  • death 

Nonmedical Treatment and Prevention

Lifestyle changes can help to prevent as well as treat atherosclerosis. Unless your atherosclerosis is severe, your doctor may recommend lifestyle changes as the first line of treatment. Lifestyle changes include:

  • eating a healthy diet that’s low in saturated fat and cholesterol
  • avoiding fatty foods
  • adding fish to your diet twice per week
  • exercising for 30 to 60 minutes per day, six days per week
  • quitting smoking if you’re a smoker
  • losing weight if you’re overweight or obese
  • managing stress
  • treating conditions associated with atherosclerosis, such as hypertension, high cholesterol, and diabetes

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