What Is Hepatitis C Viral Load?
Hepatitis C Overview
Hepatitis is a disease of the liver. There are several types of hepatitis, each named for the type of virus that causes it. The hepatitis C virus (HCV) can be transferred through contact with an infected person’s blood or during sexual contact. A mother with hepatitis C can spread the infection to her infant during childbirth. The amount of virus in the bloodstream at any given time is called the viral load.
Click through the slideshow to learn more about viral load and how hepatitis C is detected.
Hepatitis C Virus Antibody Test
An HCV antibody test is a simple blood test used for screening purposes. While this test can detect that HCV had been in your bloodstream, it can’t determine a previous infection from an active one. In some cases, a weak positive result can turn out to be a false positive.
If you test positive for HCV, it is likely that your doctor will want to follow up with additional testing that can actually measure the viral load and determine if you have an active infection.
Hepatitis C Virus RNA Assays
The HCV RNA qualitative test can tell the difference between past and current infections. This test measures the amount of virus in your blood. A third test, viral genotyping, can zero in on the specific HCV in your body. There are several different types of HCV. Knowing the specific form of HCV you have is important because the type factors into decisions regarding the treatment most likely to work for you.
Why Is the Viral Load Test Important?
Not everyone with hepatitis C has symptoms. In fact, in a small number of people, the infection resolves on its own. However, hepatitis infection can last anywhere from a few weeks to a lifetime. The illness can lead to liver damage, liver cancer, or the need for a liver transplant.
Once the proper course of treatment is determined, viral load testing can be used to monitor its success and guide future health care decisions.
Low Viral Load Versus High Viral Load
With some other infections, having a higher viral load means a higher level of illness, but that’s not the case with hepatitis C. Your viral load has no bearing on how ill you feel or how much liver damage you may experience now or in the future.
However, viral load is an important indication of how well treatment is likely to work. The lower your viral load, the more likely it is that your treatment will be successful.
Breaking Down the Numbers
A viral load of less than 615 IU/L (international units per liter) means there is no detectable hepatitis C virus, or it’s too low to detect. Additionally, a viral load of more than 800,000 IU/L is high and less than 800,000 IU/L is low. During treatment, a falling viral load is an indication that treatment is succeeding.
According to the U.S. Department of Veterans Affairs, at the end of the planned course of treatment (generally 24 or 48 weeks), an undetectable viral load means that treatment can be stopped. After that, viral load testing can alert you to a relapse.
How Often Do I Need a Viral Load Test?
Understanding the specifics of your viral load is important at the time of diagnosis. Once you begin treatment, follow-up testing will let your doctor know if the current treatment is effective. Other than that, there is no need for repeat testing. This is because the viral load doesn’t provide information about your symptoms or whether or not your liver is functioning properly. Other liver tests, such as a biopsy, can provide that information.
Who Should Be Tested and When?
Certain groups are more vulnerable to contracting HCV. Among them are dialysis patients, children born to HCV-positive mothers, and anyone who may have had contact with the blood of someone infected with hepatitis C.
There are often no symptoms of hepatitis C. Some people experience fatigue, abdominal pain, or jaundice. Those symptoms may prompt your doctor to order an HCV test. Antibodies don’t always show up in the first months after exposure. If you’ve tested positive for HCV, you should be tested for viral load. Viral load testing is also advised prior to and during treatment.
- Hepatitis C. (2012, November 16). National Institutes of Health. Retrieved November 11, 2013, from http://www.nlm.nih.gov/medlineplus/ency/article/000284.htm
- Hepatitis C: Frequently Asked Questions. (2013, July 24). U.S. Department of Veterans Affairs. Retrieved November 11, 2013, from http://www.hepatitis.va.gov/patient/faqs/meaning-of-viral-load.asp
- Hepatitis C RNA quantitative testing. (2013, January 3). U.S. Department of Veterans Affairs. Retrieved November 11, 2013, from http://www.hepatitis.va.gov/patient/diagnosis/labtests-RNA-quantitative-testing.asp
- Hepatitis C Testing. (2013, July 9). Lab Tests Online. Retrieved November 11, 2013, from http://labtestsonline.org/understanding/analytes/hepatitis-c/tab/test
- Treatment Decisions: Entire Lesson. (2013, January 9). U.S. Department of Veterans Affairs. Retrieved November 11, 2013, from http://www.hepatitis.va.gov/patient/treat/decisions-single-page.asp