Healthline Blogs

Heath Ledger's Drug Interactions

TEXT SIZE: A A A

According to the Chief Medical Examiner of New York, Heath Ledger "died as the result of acute intoxication by the combined effects of oxycodone (Percocet), hydrocodone (Vicodin), diazepam (Valium), temazepam (Restoril), alprazolam (Xanax), and doxylamine (Unisom)."

To illustrate why he died, the following is a list of potential drug interactions from Epocrates, an online drug database:

1. diazepam oxycodone
caution advised, especially w/ IV benzodiazepines and IV opioids, consider dose reduction: combo may result in vasodilation, severe hypotension, CNS and respiratory depression, psychomotor impairment (additive effects)

2. diazepam temazepam
caution advised: combo may incr. risk of CNS depression, adverse effects (additive effects)

3. diazepam Vicodin
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

4. diazepam Xanax
caution advised: combo may incr. risk of CNS depression, adverse effects (additive effects)

5. oxycodone temazepam
caution advised, especially w/ IV benzodiazepines and IV opioids, consider dose reduction: combo may result in vasodilation, severe hypotension, CNS and respiratory depression, psychomotor impairment (additive effects)

6. oxycodone Vicodin
caution advised, consider dose reduction: combo may incr. risk of CNS and resp. depression, profound sedation, hypotension, other adverse effects (additive effects)

7. oxycodone Xanax
caution advised, especially w/ IV benzodiazepines and IV opioids, consider dose reduction: combo may result in vasodilation, severe hypotension, CNS and respiratory depression, psychomotor impairment (additive effects)

8. temazepam Vicodin
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

9. temazepam Xanax
caution advised: combo may incr. risk of CNS depression, adverse effects (additive effects)

10. Vicodin Xanax
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

(Also posted on Kidney Notes.)
  • 1
Was this article helpful? Yes No
Advertisement

About the Author


MD, FACP, FASN

Dr. Schwimmer's blog explores the intersection of medicine, new technologies, and the Internet.

Advertisement
Advertisement