Feb 24 2012
One of the interesting questions to emerge in MS therapies in the next few years will be the possibility of using combination therapy to slow down disease progression. This means the use of more than one medication with different mechanisms of ...
Feb 21 2012
BG 12, Part 2
In my first post on BG-12, I introduced the two major studies supporting its efficacy. No discussion of medication is complete without acknowledging the downsides, however. The most common side effects of BG-12 were flushing, headache, gastroi...
Feb 16 2012
BG 12, Part 1
One of the most exciting disease modifying medications on the horizon in the treatment of MS is currently known as BG-12. It is made by Biogen, the same company that makes Avonex and Tysabri. This is the first oral medication from this company ...
Jan 19 2012
Of all of the symptoms of MS, few make patients as miserable as a syndrome known as trigeminal neuralgia (TN). The trigeminal nerve is the nerve that carries sensation from the face to the brain, and also carries motor fibers for the muscles u...
Jan 16 2012
Transverse Myelitis, Part 2
In my previous post I reviewed the basic anatomy of the spinal cord, one of the main site of damage in MS. As with lesions in the brain, lesions in MS tend to affect the white matter and involvement of the gray matter suggests an illness other ...
Jan 12 2012
One of the most common sources of symptoms in patients with MS is from lesions in the spinal cord. The spinal cord is a relatively thin band of nervous tissue that contains the pathways that allow us to feel, move, and use the bathroom. The sp...
Jan 02 2012
Relapse Treatment, Part 2
In my previous post, I discussed the treatment of relapses, primarily through the use of intravenous (IV) steroids. In certain patients, however, IV steroids are not an option. Either they have poor intravenous access or they simply cannot tole...
Dec 29 2011
Relapse Treatment, Part 1
In a previous post, I defined an attack. In this post, I would like to talk about how neurologists treat attacks. Treating a RelapseIn almost all cases, neurologists will use high doses of intravenous corticosteroids to treat a relapse. This...
Dec 15 2011
In a previous post, I wrote that when patients start taking a new medication they should not assume that any new discomforts are side effects of the medication. Otherwise, they may end up discarding a potentially very useful medication. ...
Dec 05 2011
Optic Neuritis: Treatment and Follow-Up
The most important study of patients with optic neuritis is termed the Optic Neuritis Treatment Trial. This was a large trial carried out between 1988 and 1991 of 454 patients with acute optic neuritis. This study made important contributions...