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What are the Side Effects & Risks of Prometrium?

A document that reads Prior to my taking Prometrium, an FDA approved, bioidentical, oral progesterone, I used bioidentical progesterone in a cream form, which I purchased from compounding pharmacies. I was careful to only purchase the highest grade and quality I could find (read: expensive), and used it happily for several years with no negative side-effects.

Last year, on the advice of my academic mentor, also a women’s health and medical writer, I decided to ask my physician for a prescription of Prometrium. Another motivating factor for me trying Prometrium was that given it is FDA approved, it is also covered by my insurance plan.  

In my research over the years, I’ve never run across any studies citing negative side-effects or risks associated with bioidentical progesterone. In fact, most of what I’ve ever read has been positive, and even emphasized the lack of research pointing to serious risks or side effects.

So imagine my surprise when I recently learned that the list of known side-effects and risks associated with Prometrium is actually very long. Given my positive experience with bioidentical progesterone, I was blithely unaware, and truly blissful in my ignorance.

So for all of you faithful and loyal readers who have relied on me for accurate and trustworthy information regarding perimenopause, and treatments for the symptoms of perimenopause, I offer my most humble apologies. Frankly, I should have known, and provided this information sooner. But, like you, I’m continuing to learn and expand my knowledge of perimenopause. And so, in the words of my favorite poet, Maya Angelou, “when you know better, you do better.”

Because this list is so long, I will not write them all out for you in this post. Instead, I will provide the link to the website at the end of this post, and let you check them out for yourself.  

But, before you trot off to read the list, I would like to point something out which I think is very important to understand.  There was a time in our medical system when physicians and pharmaceutical companies were not required to disclose every known possible side-effect or risk associated with a drug.

In addition, given that physicians were usually privy to the studies and research associated with the drugs, they had the discretion to determine which side-effects and risks were relevant to discuss with their patients and which were not. 

Since then, and more specifically, in the past fifty years or so, consumer protection laws have been implemented which require that all known risks and side-effects, even the most remote or negligible, be disclosed to consumers.  

Bearing this in mind, you should discuss any and all concerns you might have with your physician or healthcare provider to determine if Prometrium is right for you. For me personally, I have only experienced positive benefits from using Prometrium, and I have no plans in my near future to stop using it. 

You can find the list of known risks and side-effects associated with Prometrium, here at

Magnolia Miller is a certified healthcare consumer advocate in women's health and a women's freelance health writer and blogger at The Perimenopause Blog.

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Tags: Hormone Therapy

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About the Author

Magnolia is dedicated to empowering women to take responsibility for their own health.