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Fruit of the Womb
Fruit of the Womb
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  • Plasminogen Activator Inhibitor-1 (PAI-1): Role in Adverse Pregnancy Outcome? - 2 - Late Pregnancy Complications

    In our last post, we discussed the role of plasminogen activator inhibitor-1 (PAI-1) in helping to maintain the balance between the clotting and fibrinolytic (clot-dissolving) sides of the coagulation system. The primary function of PAI-1 is to i...

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  • Cervical Dysplasia and Cancer in Pregnancy - 4

    Since our last post, a reader asked the simple question, “if the patient has an abnormal Pap smear and it is not cancer, then what is it?” Although my specialty is Maternal-Fetal Medicine, and I have no delusions (or desire) to be a cancer special...

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  • Hypertensive Disorders in Pregnancy - 4

    In our last post, we mentioned that preeclampsia is often the end-stage clinical manifestation of irreversible pathologic changes that take place early in pregnancy. Indeed, there is good evidence that abnormal early placental development plays a ...

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  • Diabetes in Pregnancy - 4 - Window to Risk of Type 2 Diabetes

    Back in August of this year, I started a series on “Diabetes in Pregnancy.” A recent reader reminded me that I hadn’t gotten around to finishing that series (which is true because I got distracted by other topics). In the first three installment...

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  • Pre-op Dr T!

    Well, in about one hour and forty-five minutes I will become a ‘patient’ myself. That’s because at midnight, I can no longer eat or drink anything until after I have had my left shoulder operated on in the morning. I am NOT looking forward to th...

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  • Amniotic Fluid - 2 - Assessment of Amniotic Fluid Volume

    We closed our last post with the comment that BOTH too much fluid (polyhydramnios, otherwise termed hydramnios) or too little fluid (oligohydramnios) are associated with fetal abnormalities and/or poor perinatal outcome. In fact, the greater the ...

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  • Grand Rounds 3.32 - Thanks to MyThreeShrinks

    Thanks to MyThreeShrinks at Shrink Rap for including a link to my post "Second Verse Different from the First" in this week's Grand Rounds 3.32. This contribution addresses the care of an OB patient who had a tragic pregnancy outcome, followed by ...

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  • Tales of Two Thrombophilias

    Although we strive to practice “evidence-based medicine” when the evidence is good and the practice is sensible, there are many times when personal experience still plays a role in patient care activities. Nowhere does this seem to be more true i...

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  • Chromosomal Mosaicism Detected at the Time of Chorionic Villus Sampling

    Since the widespread acceptance of first trimester screening for fetal chromosomal abnormalities (aneuploidy), and following the recommendations that this should be offered to all pregnant women, not just those considered to be ‘at risk’ for indic...

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  • What is Aneuploidy Screening?

    Patients have a hard time understanding the differences between screening tests and diagnostic tests. The most misunderstandings or misconceptions that seem to arise during pregnancy revolve around screening for aneuploidy (fetal chromosomal abno...

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About the Author

Dr. Trofatter is an expert on maternal-fetal medicine.

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