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Zoledronic Acid Solution for injection

It is used to treat Paget's disease and osteoporosis in women

Generic Name: zoledronic acid  |  Brand Name: Aclasta

Brand Names: Zometa, Reclast, Aclasta, Zometa Concentrate

There is an FDA Alert for this drug. Click here to view it.

What is this medicine?

ZOLEDRONIC ACID (ZOE le dron ik AS id) lowers the amount of calcium loss from bone. It is used to treat Paget's disease and osteoporosis in women.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • aspirin-sensitive asthma
  • dental disease
  • kidney disease
  • low levels of calcium in the blood
  • past surgery on the parathyroid gland or intestines
  • an unusual or allergic reaction to zoledronic acid, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This medicine is for infusion into a vein. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. This medicine is not approved for use in children.

What if I miss a dose?

It is important not to miss your dose. Call your doctor or health care professional if you are unable to keep an appointment.

What may interact with this medicine?

  • certain antibiotics given by injection
  • NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
  • some diuretics like bumetanide, furosemide
  • teriparatide

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checkups. It may be some time before you see the benefit from this medicine. Do not stop taking your medicine unless your doctor tells you to. Your doctor may order blood tests or other tests to see how you are doing.

Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information.

You should make sure that you get enough calcium and vitamin D while you are taking this medicine. Discuss the foods you eat and the vitamins you take with your health care professional.

Some people who take this medicine have severe bone, joint, and/or muscle pain. This medicine may also increase your risk for a broken thigh bone. Tell your doctor right away if you have pain in your upper leg or groin. Tell your doctor if you have any pain that does not go away or that gets worse.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • breathing problems
  • changes in vision
  • feeling faint or lightheaded, falls
  • jaw burning, cramping, or pain
  • muscle cramps, stiffness, or weakness
  • trouble passing urine or change in the amount of urine

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • bone, joint, or muscle pain
  • fever
  • irritation at site where injected
  • loss of appetite
  • nausea, vomiting
  • stomach upset
  • tired

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.


Last Updated: June 15, 2012
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