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Vemurafenib Oral tablet

It targets specific cancer cells and stops the cancer cells from growing

Generic Name: vemurafenib

Brand Names: Zelboraf

What is this medicine?

VEMURAFENIB (Vem ue RAF e nib) is a chemotherapy drug. It targets specific cancer cells and stops the cancer cells from growing. It is used to treat certain types of melanoma skin cancer.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

-eye disease, vision problems
-heart disease
-history of irregular heartbeat
-history of low levels of calcium, magnesium, or potassium in the blood
-kidney disease
-liver disease
-an unusual or allergic reaction to vemurafenib, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Do not cut, crush or chew this medicine. You can take it with or without food. If it upsets your stomach, take it with food. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice. Take doses approximately 12 hours apart.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you've taken too much of this medicine contact a poison control center or emergency room at once.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is less than 4 hours until your next scheduled dose, do not make up for the missed dose and just take your next dose at your regular time. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

-arsenic trioxide
-astemizole
-certain medicines for irregular heart beat like amiodarone, bepridil, dofetilide, encainide, flecainide, propafenone, quinidine
-chloroquine
-chlorpromazine
-cisapride
-clarithromycin
-dextromethorphan; quinidine
-dronedarone
-droperidol
-erythromycin
-grepafloxacin
-halofantrine
-haloperidol
-levomethadyl
-mesoridazine
-methadone
-pentamidine
-pimozide
-posaconazole
-probucol
-propafenone
-saquinavir
-sparfloxacin
-terfenadine
-thioridazine
-troleandomycin
-ziprasidone
This medicine may also interact with the following medications:

-antiviral medicines for HIV or AIDS
-caffeine
-certain medicines for fungal infections like ketoconazole, itraconazole, or voriconazole
-certain medicines for seizures like carbamazepine, phenobarbital, phenytoin
-certain medicines that treat or prevent blood clots like warfarin
-dextromethorphan
-nefazodone
-midazolam
-rifabutin
-rifampin
-rifapentine
-St. John's wort, Hypericum perforatum
-telithromycin


Last Updated: July 11, 2013
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