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Trazodone Hydrochloride Oral tablet, extended release 24 hour

It is used to treat depression.

Generic Name: Oleptro

What is this medicine?

TRAZODONE (TRAZ oh done) is used to treat depression.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • attempted suicide or thinking about it
  • bipolar disorder
  • bleeding problems
  • heart disease, or previous heart attack
  • irregular heart beat
  • kidney disease
  • liver disease
  • low levels of sodium in the blood
  • an unusual or allergic reaction to trazodone, other medicines, foods, dyes or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take this medicine on an empty stomach, at least 30 minutes before or 2 hours after food. Do not take with food. Do not crush or chew this medicine. You may break in half along the score line. Take your medicine at bedtime everyday. Do not take your medicine more often than directed. Do not stop taking this medicine suddenly except upon the advice of your doctor. Stopping this medicine too quickly may cause serious side effects or your condition may worsen.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • cisapride
  • dofetilide
  • dronedarone
  • fluconazole
  • linezolid
  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
  • mesoridazine
  • methylene blue (injected into a vein)
  • pimozide
  • posaconazole
  • saquinavir
  • thioridazine
  • ziprasidone

This medicine may also interact with the following medications:

  • alcohol
  • antiviral medicines for HIV or AIDS
  • aspirin and aspirin-like medicines
  • barbiturates such as phenobarbital
  • certain medicines that treat or prevent blood clots like warfarin, enoxaparin, and dalteparin
  • certain medicines for blood pressure, heart disease, irregular heart beat
  • certain medicines for depression, anxiety, or psychotic disturbances
  • certain medicines for migraine headache like almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan
  • certain medicines for sleep
  • digoxin
  • fentanyl
  • ketoconazole
  • lithium
  • medicines for seizures like carbamazepine and phenytoin
  • NSAIDS, medicines for pain and inflammation, like ibuprofen or naproxen
  • rasagiline
  • supplements like St. John's wort, kava kava, valerian
  • tramadol
  • tryptophan


Last Updated: May 03, 2013
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