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Tranylcypromine Sulfate Oral tablet

It is used to treat depression

Generic Name: tranylcypromine

Brand Names: Parnate, Tranylcypromine Sulfate

There is an FDA Alert for this drug. Click here to view it.

    Suicidality
  • Antidepressants may increase risk of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults (18–24 years of age) with major depressive disorder and other psychiatric disorders; balance this risk with clinical need. Tranylcypromine is not approved for use in pediatric patients. (See Pediatric Use under Cautions.)
  • In pooled data analyses, risk of suicidality was not increased in adults >24 years of age and apparently was reduced in adults ≥65 years of age with antidepressant therapy compared with placebo.
  • Depression and certain other psychiatric disorders are themselves associated with an increased risk of suicide.
  • Appropriately monitor and closely observe all patients who are started on tranylcypromine therapy for clinical worsening, suicidality, or unusual changes in behavior; involve family members and/or caregivers in this process. (See Worsening of Depression and Suicidality Risk and Pediatric Use under Cautions.)

What is this medicine?

TRANYLCYPROMINE (tran il SIP roe meen) is an monoamine oxidase inhibitor (MAOI). It is used to treat depression.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • bipolar disorder or mania
  • frequently drink alcohol-containing beverages
  • headaches or migraine
  • heart or blood vessel disease, or irregular heart beats
  • high blood pressure
  • kidney disease
  • liver disease
  • Parkinson's disease
  • pheochromocytoma
  • recent head trauma
  • seizures or convulsions
  • schizophrenia or psychosis
  • stroke or other cerebrovascular disease
  • suicidal thoughts or a previous suicide attempt
  • an unusual or allergic reaction to tranylcypromine, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking this medicine suddenly except upon the advice of your doctor. Stopping this medicine too quickly may cause serious side effects or your condition may worsen.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • altretamine
  • atomoxetine
  • brimonidine
  • buspirone
  • caffeine
  • carbamazepine
  • certain medicines for blood pressure like guanabenz, guanadrel, guanethidine, or reserpine
  • cocaine
  • cyclobenzaprine
  • dextromethorphan
  • diet pills or stimulants, like amphetamines or ephedra
  • diphenoxylate
  • disulfiram
  • doxapram
  • ephedrine
  • general or local anesthetics
  • ginseng
  • green tea
  • guarana
  • isoniazid
  • linezolid
  • MAOIs like Azilect, Carbex, Eldepryl, Nardil, and Parnate
  • medicines for high blood pressure
  • medicines for migraine headaches
  • medicines for movement abnormalities as in Parkinson's disease like entacapone, levodopa, selegiline, tolcapone
  • meperidine
  • methylene blue
  • other medicines for mental depression, anxiety, or mood or mental problems
  • prescription pain medicines
  • procarbazine
  • SAM-e
  • St. John's wort
  • succinylcholine
  • tramadol
  • tyramine (found in cheese, red wine, beer, chocolate and other foods)
  • tryptophan
  • yohimbine

This medicine may also interact with the following medications:

  • medicines for diabetes
  • phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine


Last Updated: May 06, 2013
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