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Trandolapril, Verapamil Hydrochloride Oral tablet, extended release

It is used to treat high blood pressure

Generic Name: trandolapril-verapamil

Brand Names: Tarka

What is this medicine?

TRANDOLAPRIL; VERAPAMIL (tran DOLE a pril; ver AP a mil) is a combination of two drugs. It is used to treat high blood pressure.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • bone marrow disease
  • collagen-vascular disease like scleroderma
  • heart or blood vessel disease
  • if you are on a special diet, such as a low-salt diet
  • immune system disease like lupus
  • kidney or liver disease
  • low blood pressure
  • previous swelling of the tongue, face, or lips with difficulty breathing, difficulty swallowing, hoarseness, or tightening of the throat
  • slow or irregular heartbeat
  • an unusual or allergic reaction to trandolapril, verapamil, other medicines, insect venom, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Swallow whole. Do not break, crush or chew. Take this medicine with food. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on the advice of your doctor or health care professional.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • alfuzosin
  • cisapride
  • disopyramide
  • dofetilide
  • pimozide
  • red yeast rice

This medicine may also interact with the following medications:

  • barbiturates such as phenobarbital
  • cimetidine
  • cyclosporine
  • diuretics
  • grapefruit juice
  • lithium
  • local anesthetics or general anesthetics
  • medicines for heart-rhythm problems like amiodarone, digoxin, flecainide, procainamide, quinidine
  • medicines for high blood pressure or heart problems
  • medicines for seizures like carbamazepine and phenytoin
  • potassium salts or potassium supplements
  • rifampin, rifabutin, rifapentine
  • theophylline or aminophylline

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. Check your blood pressure as directed. Ask your doctor or health care professional what your blood pressure should be and when you should contact him or her. Call your doctor or health care professional if you notice an irregular or fast heart beat.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this drug affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can make you more drowsy and dizzy. Avoid alcoholic drinks.

Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information.

Check with your doctor or health care professional if you get an attack of severe diarrhea, nausea and vomiting, or if you sweat a lot. The loss of too much body fluid can make it dangerous for you to take this medicine.

Avoid salt substitutes unless you are told otherwise by your doctor or health care professional.

Do not treat yourself for coughs, colds, or pain while you are taking this medicine without asking your doctor or health care professional for advice. Some ingredients may increase your blood pressure.

This medicine can sometimes cause dental problems for some patients. Clean and floss your teeth carefully and regularly. Check with your dentist if your gums get swollen or inflamed and have the dentist clean your teeth regularly.


Last Updated: September 03, 2009
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