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Tenecteplase Solution for injection

It is used to dissolve blood clots that form in certain blood vessels

Generic Name: tenecteplase

Brand Names: TNKase

What is this medicine?

TENECTEPLASE (TEN neck te place) is used to dissolve blood clots that form in certain blood vessels. This medicine is used when a blood clot in a heart artery causes a heart attack.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • aneurysm
  • bleeding problems or problems with blood clotting
  • diabetic retinopathy or bleeding problems of the eye
  • endocarditis (infection of the heart valves)
  • head injury, brain disease, or tumor
  • high blood pressure
  • infection
  • irregular heartbeats
  • kidney disease
  • liver disease
  • mitral stenosis
  • recent biopsy, childbirth, surgery, or trauma (injury)
  • recent history of stroke
  • stomach ulcer or bleeding ulcer
  • an unusual or allergic reaction to tenecteplase, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This medicine is for injection into a vein. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

This does not apply.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • aminocaproic acid
  • aprotinin
  • tranexamic acid

This medicine may also interact with the following medications:

  • antiplatelet drugs such as ticlopidine or clopidogrel
  • aspirin and aspirin-like drugs
  • medicines that treat or prevent blood clots like warfarin, heparin, enoxaparin, and dalteparin
  • NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen

What should I watch for while using this medicine?

You will be closely monitored to check your progress after you receive this medicine. Follow the advice of your doctor or health care professional exactly. You may need bed rest to minimize the risk of bleeding.

This medicine can make you bleed more easily. This effect can last for several days. Try to avoid damage to your teeth and gums when you brush or floss your teeth, and to avoid any other injury to yourself.

Do not take aspirin, ibuprofen, or other nonprescription pain relievers during or for several days after this medicine unless otherwise instructed by your doctor or health care professional.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • blood in the urine, stools, or vomit
  • breathing problems
  • chest pain or tightness
  • constipation or black tarry stools
  • fever
  • severe headache
  • slow or fast heart rate
  • unusual bleeding or bruising

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • dizziness, lightheadedness
  • nausea, vomiting

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.


Last Updated: September 03, 2009
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