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Tapentadol Oral tablet, extended release

It is used to treat moderate to severe pain that lasts for more than a few days

Generic Name: Nucynta ER

What is this medicine?

TAPENTADOL (ta PEN ta dol) is a pain reliever. It is used to treat moderate to severe pain that lasts for more than a few days. It is also used to treat nerve pain caused by diabetes.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • Addison's disease
  • gallbladder disease
  • head injury
  • history of a drug or alcohol abuse problem
  • if you often drink alcohol
  • kidney disease
  • liver disease
  • low blood pressure
  • lung or breathing disease, like asthma
  • mental illness
  • prostate disease
  • seizures
  • stomach or intestine problems
  • thyroid disease
  • an unusual or allergic reaction to tapentadol, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Do not cut, crush, or chew this medicine. Do not take a tablet that is not whole. A broken or crushed tablet can be very dangerous. You may get too much medicine. Swallow only one tablet at a time. Do not wet, soak, or lick the tablet before you take it. You can take it with or without food. If it upsets your stomach, take it with food. Follow the directions on the prescription label. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you've taken too much of this medicine contact a poison control center or emergency room at once.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • alcohol or any product that contains alcohol
  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate

This medicine may also interact with the following medications:

  • antihistamines for allergy, cough, and cold
  • atropine
  • buprenorphine
  • certain medicines for bladder problems like oxybutynin, tolterodine
  • certain medicines for depression, anxiety, or psychotic disturbances
  • certain medicines for migraine headache like almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan
  • certain medicines for Parkinson's disease like benztropine, trihexyphenidyl
  • certain medicines for stomach problems like dicyclomine, hyoscyamine
  • certain medicines for travel sickness like scopolamine
  • ipratropium
  • medicines for seizures like carbamazepine, phenobarbital, phenytoin
  • medicines for sleep
  • muscle relaxants
  • narcotic medicines (opiates) for pain
  • phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine


Last Updated: August 30, 2012
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