Drugs A - Z

Sulfasalazine Oral tablet, delayed-release

It is for ulcerative colitis and certain types of rheumatoid arthritis.

Generic Name: sulfasalazine  |  Brand Name: Azulfidine EN-tabs

Brand Names: Azulfidine EN-tabs, Azulfidine, Sulfazine

What is this medicine?

SULFASALAZINE (sul fa SAL a zeen) is for ulcerative colitis and certain types of rheumatoid arthritis.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • asthma
  • blood disorders or anemia
  • glucose-6-phosphate dehydrogenase (G6PD) deficiency
  • intestinal obstruction
  • kidney disease
  • liver disease
  • porphyria
  • urinary tract obstruction
  • an unusual reaction to sulfasalazine, sulfa drugs, salicylates, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a full glass of water. Follow the directions on the prescription label. If the medicine upsets your stomach, take it with food or milk. Do not crush or chew the tablets. Swallow the tablets whole. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed. While this drug may be prescribed for children as young as 6 years for selected conditions, precautions do apply.

Patients over 65 years old may have a stronger reaction and need a smaller dose.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

  • digoxin
  • folic acid

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. You will need frequent blood and urine checks.

This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

Drink plenty of water while taking this medicine.

Tell your doctor if you see the tablet in your stools. Your body may not be absorbing the medicine.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • fever, chills, or any other sign of infection
  • painful, difficult, or reduced urination
  • redness, blistering, peeling or loosening of the skin, including inside the mouth
  • severe stomach pain
  • unusual bleeding or bruising
  • unusually weak or tired
  • yellowing of the skin or eyes

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • headache
  • loss of appetite
  • nausea, vomiting
  • orange color to the urine
  • reduced sperm count

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.


Last Updated: August 21, 2009
Licensed from
The Healthline Site, its content, such as text, graphics, images, search results, HealthMaps, Trust Marks, and other material contained on the Healthline Site ("Content"), its services, and any information or material posted on the Healthline Site by third parties are provided for informational purposes only. None of the foregoing is a substitute for professional medical advice, examination, diagnosis, or treatment. Always seek the advice of a physician or other qualified healthcare provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on the Healthline Site. If you think you may have a medical emergency, call your doctor or 911 immediately. Please read the Terms of Service for more information regarding use of the Healthline Site.
Azulfidine En-Tabs Images

Advertisement
Advertisement