Drugs A - Z

Streptomycin Sulfate Solution for injection

It is used to treat certain kinds of bacterial infections

Generic Name: streptomycin

Brand Names: Streptomycin Sulfate

There is an FDA Alert for this drug. Click here to view it.

    Neurotoxicity and Ototoxicity
  • Neurotoxicity may occur, including disturbances of vestibular and cochlear function, optic nerve dysfunction, peripheral neuritis, arachnoiditis, and encephalopathy.
  • Risk of severe neurotoxic reactions is increased in patients with impaired renal function or prerenal azotemia.
  • High incidence of clinically detectable, irreversible vestibular damage.

    Nephrotoxicity
  • Use reduced dosage in patients with renal impairment and/or nitrogen retention.
  • Maintain serum streptomycin concentrations <20–25 mcg/mL in patients with kidney damage.

    Patient Monitoring
  • Carefully monitor renal function.
  • Use streptomycin only when adequate laboratory and audiometric testing facilities are available during therapy.

    Neuromuscular Blockade
  • Respiratory paralysis from neuromuscular blockade may occur.
  • Consider possibility of neuromuscular blockade and respiratory paralysis when administering aminoglycosides, especially concurrently with anesthetics or neuromuscular blocking agents. (See Interactions.)

    Interactions
  • Avoid concurrent and/or sequential use of other neurotoxic or nephrotoxic drugs, including cephaloridine (no longer available in the US), colistimethate/colistin, cyclosporine, gentamicin, kanamycin, neomycin, paromomycin, polymyxin B, tobramycin, and viomycin. (See Interactions.)

What is this medicine?

STREPTOMYCIN (strep toe MYE sin) is an aminoglycoside antibiotic. It is used to treat certain kinds of bacterial infections. It will not work for colds, flu, or other viral infections.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • hearing problems
  • kidney disease
  • an unusual or allergic reaction to streptomycin, other aminoglycosides or medicines, sulfites, foods, dyes or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This medicine is for injection into a muscle. It is usually given by a health care professional in a hospital or clinic setting.

If you get this medicine at home, you will be taught how to prepare and give this medicine. Use exactly as directed. Take your medicine at regular intervals. Do not take your medicine more often than directed.

It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or healthcare provider to get one.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for selected conditions, precautions do apply

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • cephaloridine
  • cidofovir
  • colistin
  • cyclosporine
  • other aminoglycoside antibiotics
  • polymyxin
  • viomycin

This medicine may also interact with the following medications:

  • anesthesia drugs
  • diuretics
  • muscle relaxers

What should I watch for while using this medicine?

Tell your doctor or health care professional if your symptoms do not start to get better or if they get worse. Your condition, including your hearing and lab work, will be monitored while you are taking this medicine.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • breathing problems
  • change in amount or color of urine
  • change in hearing
  • fever
  • loss of balance
  • pain, tingling, numbness in the hands or feet
  • redness, blistering, peeling or loosening of the skin, including inside the mouth
  • unusual bleeding or bruising
  • unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • headache
  • nausea, vomiting
  • pain or swelling at site where injected

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.


Last Updated: August 18, 2009
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