Drugs A - Z

Stavudine Oral solution

It is used with other medicines to treat HIV

Generic Name: stavudine  |  Brand Name: Zerit

Brand Names: Zerit, Zerit XR

There is an FDA Alert for this drug. Click here to view it.

  • Lactic acidosis and severe hepatomegaly with steatosis (including some fatalities) reported rarely in patients receiving nucleoside reverse transcriptase inhibitors (NRTIs) alone or in conjunction with other antiretrovirals. (See Lactic Acidosis and Severe Hepatomegaly with Steatosis under Cautions.)
  • Fatal lactic acidosis reported in pregnant women receiving stavudine and didanosine with other antiretrovirals. Stavudine in conjunction with didanosine should be used with caution in pregnant women and only if potential benefits outweigh potential risks. (See Pregnancy under Cautions.)
  • Fatal and nonfatal pancreatitis reported in patients receiving stavudine and didanosine with or without hydroxyurea. (See Pancreatitis under Cautions.)

REMS:

FDA approved a REMS for stavudine to ensure that the benefits of a drug outweigh the risks. However, FDA later rescinded REMS requirements. See the FDA REMS page ([Web]) or the ASHP REMS Resource Center ([Web]).

What is this medicine?

STAVUDINE, d4T (STAV yoo deen) is an antiretroviral medicine. It is used with other medicines to treat HIV. This medicine is not a cure for HIV. It will not stop the spread of HIV to others.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • diabetes
  • drink alcohol daily
  • gallstones
  • kidney disease
  • liver disease
  • history of pancreatitis
  • tingling, numbness in the hands, feet
  • an unusual or allergic reaction to stavudine, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Shake well before using. Use a specially marked spoon, or container to measure the dose. Household spoons are not accurate. You may take this medicine with or without food. Take your medicine at regular intervals. Do not take your medicine more often than directed. For your anti-HIV therapy to work as well as possible, take each dose exactly as prescribed. Do not skip doses or stop your medicine even if you feel better. Skipping doses may make the HIV virus resistant to this medicine and other medicines. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as newborns for selected conditions, precautions do apply.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • zalcitabine, ddC
  • zidovudine, AZT

This medicine may also interact with the following medications:

  • didanosine, ddI
  • doxorubicin
  • hydroxyurea
  • interferon
  • ribavirin

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular check ups. Discuss any new symptoms with your doctor. You will need to have important blood work done while on this medicine.

HIV is spread to others through sexual or blood contact. Talk to your doctor about how to stop the spread of HIV.

Do not treat severe stomach pain, nausea or vomiting with over-the-counter medicines. Contact your doctor.

This medicine may affect blood sugar levels. If you have diabetes, check with your doctor or health care professional before you change your diet or the dose of your diabetic medicine.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • breathing difficulties
  • increased hunger or thirst
  • increased urination
  • muscle weakness in arms and legs
  • nausea, vomiting, unusual stomach upset or pain
  • tingling, pain, burning, or numbness in the hands or feet
  • unusual bleeding or bruising
  • unusually weak or tired
  • weight gain around waist, back, or thinning of face, arms, legs

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • diarrhea
  • difficulty sleeping
  • fever, chills
  • headache
  • loss of appetite
  • muscle pain
  • weight loss

Where should I keep my medicine?

Keep out of the reach of children.

After this medicine is mixed by your pharmacist, store it in a refrigerator between 2 and 8 degrees C (36 and 46 degrees F). Do not freeze. Throw away any unused medicine after 30 days.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.


Last Updated: August 18, 2009
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