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Sotalol Hydrochloride Oral tablet [Atrial Arrhythmias]

Beta-blockers reduce the workload on the heart and help it to beat more regularly

Generic Name: sotalol

Brand Names: Sorine, Sotalol Hydrochloride AF, Sotalol Hydrochloride, Betapace, Betapace AF

There is an FDA Alert for this drug. Click here to view it.

  • To minimize the risk of induced arrhythmias, patients initiated or re-initiated on sotalol should be placed in a facility that can provide cardiac resuscitation and continuous ECG monitoring for at least 3 days (on maintenance dosage). (See Proarrhythmic Effects under Cautions.)
  • Calculate Clcr prior to dosing. (See General under Dosage and Administration.)
  • Sotalol is marketed in the US under separate trade names for ventricular (Betapace®) or atrial (Betapace AF®) arrhythmias.
  • Betapace® is not approved for atrial arrhythmias, and should not be substituted for Betapace AF® because professional labeling differs (e.g., for cautions, precautions, and contraindications; patient instructions and advice; and dosage and administration) for the products, and only Betapace AF® is distributed with patient labeling appropriate for patients with atrial arrhythmias.

What is this medicine?

SOTALOL (SOE ta lole) is a beta-blocker. Beta-blockers reduce the workload on the heart and help it to beat more regularly. This medicine is used to treat patients with an atrial heart arrhythmia such as atrial fibrillation. This medicine can help your heart return to and maintain a normal rhythm.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • diabetes
  • heart or vessel disease like slow heart rate, worsening heart failure, heart block, sick sinus syndrome or Raynaud's disease
  • history of low levels of potassium or magnesium
  • kidney disease
  • liver disease
  • lung or breathing disease, like asthma or emphysema
  • pheochromocytoma
  • recent heart attack
  • thyroid disease
  • an unusual or allergic reaction to sotalol, other beta-blockers, medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking this medicine suddenly. This could lead to serious heart-related effects.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed. While this medicine may be used in children for selected conditions precautions do apply.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • amoxapine
  • arsenic trioxide
  • certain antibiotics like gatifloxacin, grepafloxacin, levofloxacin, moxifloxacin, sparfloxacin, telithromycin
  • cisapride
  • droperidol
  • haloperidol
  • hawthorn
  • levomethadyl
  • maprotiline
  • medicines for malaria like chloroquine and halofantrine
  • medicines to control heart rhythm
  • methadone
  • other beta-blockers like atenolol, metoprolol, propranolol and others
  • pentamidine
  • phenothiazines like prochlorperazine, perphenazine, thioridazine, and others
  • pimozide
  • ranolazine
  • tricyclic antidepressants like amitriptyline, imipramine, nortriptyline, and others
  • vardenafil
  • ziprasidone

This medicine may also interact with the following medications:

  • antacids
  • certain antibiotics such as clarithromycin and erythromycin
  • clonidine
  • digoxin
  • medicines for angina or high blood pressure
  • medicines for colds and breathing difficulties
  • medicines for diabetes

What should I watch for while using this medicine?

You will be started on this medicine in a specialized facility for the first two or more days of treatment. Visit your doctor or health care professional for regular checks on your progress. Check your heart rate and blood pressure regularly while you are taking this medicine. Ask your doctor or health care professional what your heart rate and blood pressure should be, and when you should contact him or her. Your doctor or health care professional also may schedule regular blood tests and electrocardiograms to check your progress.

Because your condition and the use of this medicine carry some risk, it is a good idea to carry an identification card, necklace or bracelet with details of your condition, medications, and doctor or health care professional.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this drug affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can make you more drowsy and dizzy. Avoid alcoholic drinks.

Do not treat yourself for coughs, colds, or pain while you are taking this medicine without asking your doctor or health care professional for advice. Some ingredients may increase your blood pressure.

If you are going to have surgery, tell your doctor or health care professional that you are taking this medicine.


Last Updated: August 19, 2009
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