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Sertraline Hydrochloride Oral tablet

It is used to treat depression

Generic Name: sertraline  |  Brand Name: Zoloft

Brand Names: Zoloft

There is an FDA Alert for this drug. Click here to view it.

    Suicidality
  • Antidepressants may increase risk of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults (18–24 years of age) with major depressive disorder and other psychiatric disorders; balance this risk with clinical need. Sertraline is not approved for use in pediatric patients except for patients with obsessive-compulsive disorder. (See Pediatric Use under Cautions.)
  • In pooled data analyses, risk of suicidality was not increased in adults >24 years of age and apparently was reduced in adults ≥65 years of age with antidepressants compared with placebo.
  • Depression and certain other psychiatric disorders are themselves associated with an increased risk of suicide.
  • Appropriately monitor and closely observe all patients who are started on sertraline therapy for clinical worsening, suicidality, or unusual changes in behavior; involve family members and/or caregivers in this process. (See Worsening of Depression and Suicidality Risk under Cautions.)

What is this medicine?

SERTRALINE (SER tra leen) is used to treat depression. It may also be used to treat obsessive compulsive disorder, panic disorder, post-trauma stress, premenstrual dysphoric disorder (PMDD) or social anxiety.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • bipolar disorder or a family history of bipolar disorder
  • diabetes
  • heart disease
  • liver disease
  • receiving electroconvulsive therapy
  • seizures (convulsions)
  • suicidal thoughts, plans, or attempt by you or a family member
  • an unusual or allergic reaction to sertraline, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. You can take it with or without food. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not stop taking this medicine suddenly except upon the advice of your doctor. Stopping this medicine too quickly may cause serious side effects or your condition may worsen.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 7 years for selected conditions, precautions do apply.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • linezolid
  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
  • methylene blue (injected into a vein)
  • pimozide
  • thioridazine

This medicine may also interact with the following medications:

  • alcohol
  • aspirin and aspirin-like medicines
  • certain medicines for depression, anxiety, or psychotic disturbances
  • certain medicines for migraine headaches like almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan
  • certain medicines for seizures like carbamazepine, valproic acid, phenytoin
  • cimetidine
  • digoxin
  • diuretics
  • fentanyl
  • furazolidone
  • isoniazid
  • lithium
  • medicines that treat or prevent blood clots like warfarin, enoxaparin, and dalteparin
  • medicines to control heart rhythm like flecainide or propafenone
  • medicines for sleep
  • NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
  • procarbazine
  • rasagiline
  • supplements like St. John's wort, kava kava, valerian
  • tolbutamide
  • tramadol
  • tryptophan


Last Updated: May 03, 2013
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