Drugs A - Z

Selegiline Hydrochloride Oral disintegrating tablet

It is used with levodopa-carbidopa in the treatment of Parkinson's disease

Generic Name: selegiline

Brand Names: Carbex, Atapryl, Zelapar, Eldepryl, Selegiline Hydrochloride

There is an FDA Alert for this drug. Click here to view it.

What is this medicine?

SELEGILINE (se LE ji leen) is an monoamine oxidase inhibitor (MAOI). It is used with levodopa-carbidopa in the treatment of Parkinson's disease. It is usually added to therapy when there is a decrease in response to levodopa.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • frequently drink alcoholic beverages
  • kidney disease
  • liver disease
  • phenylketonuria
  • an unusual or allergic reaction to selegiline, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth in the morning. Follow the directions on the prescription label. Do not push the tablet through the foil backing. Peel back the foil with dry hands, gently remove the tablet, and immediately place the tablet on your tongue. It will dissolve in seconds. Do not swallow it. Wait about 5 minutes after taking your medicine before ingesting any food or liquid. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on the advice of your doctor or health care professional.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • other medicines containing selegiline, like Emsam
  • altretamine
  • atomoxetine
  • caffeine
  • carbamazepine
  • certain medicines for depression, anxiety, or psychotic disturbances
  • cocaine
  • dextromethorphan
  • diphenoxylate
  • ephedrine
  • fluoxetine
  • herbal medicines like ginseng, green tea, guarana, SAM-e, and St. John's Wort
  • isoniazid
  • linezolid
  • local anesthetics
  • MAOIs like Marplan, Nardil, and Parnate
  • medicines for migraine headaches
  • meperidine
  • methylene blue
  • procarbazine
  • pseudoephedrine
  • rasagiline
  • stimulants like amphetamine, dextroamphetamine or methylphenidate
  • tramadol
  • tryptophan

This medicine may also interact with the following medications:

  • medicines for high blood pressure
  • prescription pain medicines

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. It can take up to 4 weeks to see the full effects of this medicine. Do not suddenly stop taking your medicine. This may make your condition worse or give you withdrawal symptoms. Ask your doctor or health care professional for advice about gradually reducing your dosage. Even after you stop taking this medicine the effects can last for at least two weeks.

Patients and their families should watch out for depression or thoughts of suicide that get worse. Also watch out for sudden or severe changes in feelings such as feeling anxious, agitated, panicky, irritable, hostile, aggressive, impulsive, severely restless, overly excited and hyperactive, or not being able to sleep. If this happens, especially at the beginning of antidepressant treatment or after a change in dose, call your health care professional.

This medicine can interact with certain foods that contain high amounts of tyramine. The combination may cause severe headaches, a rise in blood pressure, or irregular heart beat. Foods that contain significant amounts of tyramine include aged cheeses, meats and fish (especially aged, smoked, pickled, or processed such as bologna, pepperoni, salami, summer sausage), beer and ale, alcohol-free beer, wine (especially red), sherry, hard liquor, liqueurs, avocados, bananas, figs, raisins, soy sauce, miso soup, yeast/protein extracts, bean curd, fava or broad bean pods, or any over-ripe fruit. Ask your doctor or health care professional, pharmacist, or nutritionist for a complete listing of tyramine-containing foods.

You may get drowsy, dizzy or have blurred vision. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may increase dizziness or drowsiness. Do not drink alcoholic beverages while taking this medicine.

This medicine can make your mouth dry. Chewing sugarless gum, sucking hard candy and drinking plenty of water will help.

Do not treat yourself for coughs, colds, flu or allergies without asking your doctor or health care professional for advice. Do not take any medications for weight loss without advice either. Some ingredients in these products may increase possible side effects.

If you are diabetic there is a possibility that this medicine may affect your blood sugar. Ask your doctor or health care professional for advice if there is any change in your blood or urine sugar tests.

There have been reports of increased sexual urges or other strong urges such as gambling while taking some medicines for Parkinson's disease. If you experience any of these urges while taking this medicine, you should report it to your health care provider as soon as possible.

You should check your skin often for changes to moles and new growths while taking this medicine. Call your doctor if you notice any of these changes.


Last Updated: July 16, 2012
Licensed from
The Healthline Site, its content, such as text, graphics, images, search results, HealthMaps, Trust Marks, and other material contained on the Healthline Site ("Content"), its services, and any information or material posted on the Healthline Site by third parties are provided for informational purposes only. None of the foregoing is a substitute for professional medical advice, examination, diagnosis, or treatment. Always seek the advice of a physician or other qualified healthcare provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on the Healthline Site. If you think you may have a medical emergency, call your doctor or 911 immediately. Please read the Terms of Service for more information regarding use of the Healthline Site.
Advertisement

Recommended for You

Advertisement