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Rasburicase Solution for injection

It is used to prevent and to treat high levels of uric acid caused by cancer treatment

Generic Name: rasburicase  |  Brand Name: Elitek

Brand Names: Elitek

There is an FDA Alert for this drug. Click here to view it.

  • Risk of severe hypersensitivity reactions (e.g., anaphylaxis). (See Hypersensitivity Reactions under Cautions.)
  • Immediately and permanently discontinue if clinical evidence of hypersensitivity reaction develops.
  • Risk of severe hemolysis in patients with a glucose-6-phosphate dehydrogenase (G-6-PD) deficiency. (See Hemolysis under Cautions.)
  • Immediately and permanently discontinue if hemolysis develops.
  • Screen patients at higher risk (e.g., patients of African or Mediterranean ancestry) prior to starting therapy.
  • Methemoglobinemia reported; immediately and permanently discontinue if methemoglobinemia develops. (See Methemoglobinemia under Cautions.)
    Interference with Uric Acid Measurements
  • Enzymatic degradation of uric acid occurs within blood samples left at room temperature, resulting in spuriously low uric acid levels.
  • Collect blood in prechilled tubes containing heparin anticoagulant and immediately immerse and maintain in an ice-water bath; assay plasma samples within 4 hours of collection. (See Specific Drugs and Laboratory Tests under Interactions.)

What is this medicine?

RASBURICASE (ras BURE i kase) breaks down uric acid in the blood. It is used to prevent and to treat high levels of uric acid caused by cancer treatment.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • G6PD deficiency
  • history of anemia
  • history of blood transfusion
  • an unusual or allergic reaction to rasburicase, yeast, mannitol, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This medicine is for infusion into a vein. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 1 month old for selected conditions, precautions do apply.

What if I miss a dose?

This does not apply.

What may interact with this medicine?

  • allopurinol

What should I watch for while using this medicine?

Your condition will be monitored carefully while you are receiving this medicine. You will need to have regular blood tests during your treatment.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • blue color to lips or nailbeds
  • breathing problems
  • chest pain, tightness
  • fast, irregular heartbeat
  • feeling faint or lightheaded, falls
  • fever
  • low blood pressure
  • seizures
  • trouble passing urine or change in the amount of urine
  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • constipation or diarrhea
  • diarrhea
  • headache
  • mouth sores
  • nausea, vomiting

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Last Updated: August 17, 2009
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