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Quetiapine Fumarate Oral tablet

It is used to treat schizophrenia and bipolar disorder, also known as manic-depression

Generic Name: quetiapine

Brand Names: Seroquel XR, Seroquel

There is an FDA Alert for this drug. Click here to view it.

    Increased Mortality in Geriatric Patients
  • Substantially higher mortality rate (4.5%) in geriatric patients with dementia-related psychosis† receiving atypical antipsychotic agents (e.g., quetiapine, aripiprazole, olanzapine, risperidone) compared with those receiving placebo (2.6%).
  • Most fatalities resulted from cardiac-related events (e.g., heart failure, sudden death) or infections (mostly pneumonia).
  • Atypical antipsychotics are not approved for the treatment of dementia-related psychosis. (See Increased Mortality in Geriatric Patients with Dementia-related Psychosis under Cautions.)

What is this medicine?

QUETIAPINE (kwe TYE a peen) is an antipsychotic. It is used to treat schizophrenia and bipolar disorder, also known as manic-depression.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • brain tumor or head injury
  • breast cancer
  • cataracts
  • diabetes
  • difficulty swallowing
  • heart disease
  • kidney disease
  • liver disease
  • low blood counts, like low white cell, platelet, or red cell counts
  • low blood pressure or dizziness when standing up
  • Parkinson's disease
  • previous heart attack
  • seizures
  • suicidal thoughts, plans, or attempt by you or a family member
  • thyroid disease
  • an unusual or allergic reaction to quetiapine, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth. Swallow it with a drink of water. Follow the directions on the prescription label. If it upsets your stomach you can take it with food. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on the advice of your doctor or health care professional.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 10 years for selected conditions, precautions do apply.

Patients over age 65 years may have a stronger reaction to this medicine and need smaller doses.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • chlorpromazine
  • cisapride
  • droperidol
  • grepafloxacin
  • halofantrine
  • mesoridazine
  • pimozide
  • sparfloxacin
  • thioridazine

This medicine may also interact with the following medications:

  • alcohol
  • antifungal medicines like fluconazole, itraconazole, ketoconazole, or voriconazole
  • antiviral medicines for HIV or AIDS
  • cimetidine
  • erythromycin
  • haloperidol
  • lorazepam
  • medicines for depression, anxiety, or psychotic disturbances
  • medicines for diabetes
  • medicines for high blood pressure
  • medicines for Parkinson's disease
  • medicines for seizures like carbamazepine, phenobarbital, phenytoin
  • rifampin
  • steroid medicines like prednisone or cortisone

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. It may be several weeks before you see the full effects of this medicine.

Your health care provider may suggest that you have your eyes examined prior to starting this medicine, and every 6 months thereafter.

If you have been taking this medicine regularly for some time, do not suddenly stop taking it. You must gradually reduce the dose or your symptoms may get worse. Ask your doctor or health care professional for advice.

Patients and their families should watch out for worsening depression or thoughts of suicide. Also watch out for sudden or severe changes in feelings such as feeling anxious, agitated, panicky, irritable, hostile, aggressive, impulsive, severely restless, overly excited and hyperactive, or not being able to sleep. If this happens, especially at the beginning of antidepressant treatment or after a change in dose, call your health care professional.

You may get dizzy or drowsy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can increase dizziness and drowsiness. Avoid alcoholic drinks.

Do not treat yourself for colds, diarrhea or allergies. Ask your doctor or health care professional for advice, some ingredients may increase possible side effects.

This medicine can reduce the response of your body to heat or cold. Dress warm in cold weather and stay hydrated in hot weather. If possible, avoid extreme temperatures like saunas, hot tubs, very hot or cold showers, or activities that can cause dehydration such as vigorous exercise.


Last Updated: May 07, 2013
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