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Propofol Emulsion for injection

It is used to produce relaxation and sleep before or during surgery

Generic Name: propofol

Brand Names: Diprivan

There is an FDA Alert for this drug. Click here to view it.

    Microbial Contamination
  • Propofol injectable emulsion can support microbial growth. (See Potential for Microbial Contamination under Cautions.)
  • Use strict aseptic technique at all times during handling; failure to use aseptic technique may result in microbial contamination and possible fever, infection/sepsis, other life-threatening illness, and/or death.
  • Discard unused portions within the required time limits. (See Stability and Sterility Considerations under Dosage and Administration.)
  • Do not use if contamination is suspected.

What is this medicine?

PROPOFOL is an anesthetic. It is used to produce relaxation and sleep before or during surgery. It is also used in patients on a ventilator.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • heart disease
  • high cholesterol
  • pancreatitis
  • seizures
  • an unusual or allergic reaction to propofol, anesthetics, eggs, soy, peanuts, benzyl alcohol, sulfites, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This medicine is for infusion into a vein. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 2 months old for selected conditions, precautions do apply.

What if I miss a dose?

This does not apply.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
  • St. John's Wort

This medicine may also interact with the following medications:

  • alcohol
  • barbiturates for sleep or seizures
  • levodopa
  • medicines for depression, anxiety, or psychotic disturbances
  • medicines for sleep
  • narcotic medicines for pain
  • other medicines for sleep during surgery

What should I watch for while using this medicine?

Your condition will be monitored carefully while you are receiving this medicine.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • breathing problems
  • changes in vision
  • dark urine
  • fast, irregular heartbeat
  • feeling faint or lightheaded, falls
  • fever
  • low blood pressure
  • muscle pain or weakness
  • numbness or tingling in the hands or feet
  • seizures
  • stomach pain
  • trouble passing urine or change in the amount of urine
  • uncontrollable muscle spasm
  • unusual weakness

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • dizziness
  • nausea
  • pain at site where injected

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.


Last Updated: December 04, 2009
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