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Prochlorperazine Edisylate Solution for injection

This medicine is also used to treat schizophrenia

Generic Name: prochlorperazine  |  Brand Name: Compazine

Brand Names: Prochlorperazine Maleate, Prochlorperazine Edisylate, Compazine, Procot, Compro, Compazine Spansule

There is an FDA Alert for this drug. Click here to view it.

What is this medicine?

PROCHLORPERAZINE (proe klor PER a zeen) helps to control severe nausea and vomiting. This medicine is also used to treat schizophrenia. It can also help patients who experience anxiety that is not due to psychological illness.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • blood disorders or disease
  • dementia
  • liver disease or jaundice
  • Parkinson's disease
  • uncontrollable movement disorder
  • an unusual or allergic reaction to prochlorperazine, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This medicine is for injection into a muscle, or injection or infusion into a vein. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 2 years of age for selected conditions, precautions do apply.

What if I miss a dose?

This does not apply.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • amoxapine
  • antidepressants like citalopram, escitalopram, fluoxetine, paroxetine, and sertraline
  • deferoxamine
  • dofetilide
  • maprotiline
  • tricyclic antidepressants like amitriptyline, clomipramine, imipramine, nortriptyline and others

This medicine may also interact with the following medications:

  • lithium
  • medicines for pain
  • phenytoin
  • propranolol
  • warfarin

What should I watch for while using this medicine?

Your condition will be monitored carefully while you are receiving this medicine.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

This medicine can reduce the response of your body to heat or cold. Dress warm in cold weather and stay hydrated in hot weather. If possible, avoid extreme temperatures like saunas, hot tubs, very hot or cold showers, or activities that can cause dehydration such as vigorous exercise.

This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • abnormal production of milk in females
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • blurred vision
  • breast enlargement in both males and females
  • breathing problems
  • chest pain, fast or irregular heartbeat
  • confusion, restlessness
  • dark yellow or brown urine
  • dizziness or fainting spells
  • drooling, shaking, movement difficulty, or rigidity
  • fever, chills, sore throat
  • involuntary or uncontrollable movements of the eyes, mouth, head, arms, and legs
  • seizures
  • stomach area pain
  • unusually weak or tired
  • unusual bleeding or bruising
  • yellowing of skin or eyes

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • difficulty passing urine
  • difficulty sleeping
  • headache
  • sexual dysfunction

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.


Last Updated: May 07, 2013
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