Increased risk of severe insulin-induced hypoglycemia with concomitant pramlintide and insulin therapy, particularly in patients with type 1 diabetes.
Generally occurs within 3 hours after injection with pramlintide.
Potential for serious injuries if severe hypoglycemia occurs while operating a motor vehicle, heavy machinery, or while engaging in other high-risk activities.
Appropriate patient selection, careful patient instruction, and insulin dose adjustments required. (See Hypoglycemia under Cautions.)
PRAMLINTIDE (PRAM lin tide) is a man-made form of a hormone normally found in the body. It is used to treat type 1 and type 2 diabetes in adults. This medicine works with insulin to control blood sugar.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
This medicine is for injection under the skin. You will be taught how to prepare and give this medicine. Use exactly as directed. Do not mix this medicine with insulin in the same syringe. Take this medicine immediately before meals. Take your medicine at regular intervals. Do not take your medicine more often than directed.
Always check the appearance of this medicine before using it. Do not use it if it is cloudy or has solid particles in it.
It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or healthcare provider to get one.
A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
What if I miss a dose?
It is important not to miss a dose. Your health care professional or doctor should discuss a plan for missed doses with you. If you do miss a dose, follow their plan. Do not take double doses.
Some medications can hide the warning symptoms of low blood sugar (hypoglycemia). You may need to monitor your blood sugar more closely if you are taking one of these medications. These include:
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medicine?
Visit your doctor for regular checks on your progress. Learn how to check your blood glucose and urine ketone levels. Sometimes it is hard to tell the difference between low and high blood sugar (see side effects). Use a blood sugar measuring device, whenever possible, before you treat high or low blood sugar.
When first starting to use this medicine, you should check your blood sugar more often, especially before and after meals. This will help lower the chance of having very low blood sugars. Discuss with your health care professional or doctor the results of your blood sugar monitoring at least once a week until your blood sugars, dose of this medicine, and dose of insulin are stable.
Always carry a quick-source of sugar with you in case you have symptoms of low blood sugar. Examples include hard sugar candy or glucose tablets.
Try not to change the brand and type of syringe unless your health care professional or doctor tells you to. Use a syringe one time only.
Wear a medical ID bracelet or chain, and carry a card that describes your disease and details of your medicine and dosage times.
Many nonprescription cough and cold products contain sugar or alcohol. These can affect diabetes control or can alter the results of tests used to monitor blood sugar. Avoid alcohol. Avoid products that contain alcohol or sugar.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
increase or decrease in fatty tissue under the skin, through overuse of a particular injection site
irritation at site where injected
loss of appetite
nausea or vomiting
stomach pain
tired
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Where should I keep my medicine?
Keep out of the reach of children.
Store unopened vials in the refrigerator between 2 to 8 degrees C (36 to 46 degrees F). Do not freeze. Throw away any unused medicine after the expiration date.
Store opened vials (vials currently in use) in the refrigerator or at room temperature at or below 25 degrees C (77 degrees F). Do not freeze. Keeping this medicine at room temperature decreases the amount of pain during injection. Throw away any opened vials of this medicine 28 days after opening.
NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
Remember, keep this and all other medicines out of the reach of children,
never share your medicines with others, and use this medication only for the indication prescribed.
