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Ponatinib Oral tablet

It targets specific proteins within cancer cells and stops the cancer cell from growing

Generic Name:

What is this medicine?

PONATINIB is a chemotherapy drug. It targets specific proteins within cancer cells and stops the cancer cell from growing. This medicine is used to treat chronic myelogenous leukemia and certain types of acute lymphoblastic leukemia.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

-diabetes
-heart disease
-high blood pressure
-high cholesterol
-history of stroke
-liver disease
-recent surgery
-smoke tobacco
-an unusual or allergic reaction to ponatinib, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. You can take it with or without food. If it upsets your stomach, take it with food. Do not cut, crush, or chew this medicine. Do not take with grapefruit juice. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.
A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you've taken too much of this medicine contact a poison control center or emergency room at once.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

This medicine may interact with the following medications:

-aliskiren
-ambrisentan
-boceprevir
-carbamazepine
-clarithromycin
-colchicine
-conivaptan
-dabigatran
-digoxin
-everolimus
-fexofenadine
-grapefruit juice
-imatinib
-indinavir
-irinotecan
-itraconazole
-ketoconazole
-lapatinib
-lopinavir/ritonavir
-maraviroc
-medicines for stomach problems like cimetidine, famotidine, omeprazole, lansoprazole
-methotrexate
-mitoxantrone
-nefazodone
-nelfinavir
-nilotinib
-phenytoin
-posaconazole
-ranolazine
-rifampin
-ritonavir
-rosuvastatin
-saquinavir
-St. John's Wort
-sulfasalazine
-telaprevir
-telithromycin
-topotecan
-voriconazole

What should I watch for while using this medicine?

This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

You may need blood work done while you are taking this medicine.

If you are going to have surgery or any other procedures, tell your doctor you are taking this medicine.

Do not become pregnant while taking this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.


Last Updated: December 20, 2012
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