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Pimozide Oral tablet

It helps to reduce the muscle and speech tics that are caused by Tourette's syndrome.

Generic Name: pimozide  |  Brand Name: Orap

Brand Names: Orap

There is an FDA Alert for this drug. Click here to view it.

Special Alerts:

[Posted 02/22/2011] ISSUE: FDA notified healthcare professionals that the Pregnancy section of drug labels for the entire class of antipsychotic drugs has been updated. The new drug labels now contain more and consistent information about the potential risk for abnormal muscle movements (extrapyramidal signs or EPS) and withdrawal symptoms in newborns whose mothers were treated with these drugs during the third trimester of pregnancy.

The symptoms of EPS and withdrawal in newborns may include agitation, abnormally increased or decreased muscle tone, tremor, sleepiness, severe difficulty breathing, and difficulty in feeding. In some newborns, the symptoms subside within hours or days and do not require specific treatment; other newborns may require longer hospital stays.

BACKGROUND: Antipsychotic drugs are used to treat symptoms of psychiatric disorders such as schizophrenia and bipolar disorder.

RECOMMENDATION: Healthcare professionals should be aware of the effects of antipsychotic medications on newborns when the medications are used during pregnancy. Patients should not stop taking these medications if they become pregnant without talking to their healthcare professional, as abruptly stopping antipsychotic medications can cause significant complications for treatment. For more information visit the FDA website at: [Web] and [Web].

[Posted 06/16/2008] FDA notified healthcare professionals that both conventional and atypical antipsychotics are associated with an increased risk of mortality in elderly patients treated for dementia-related psychosis. In April 2005, FDA notified healthcare professionals that patients with dementia-related psychosis treated with atypical antipsychotic drugs are at an increased risk of death. Since issuing that notification, FDA has reviewed additional information that indicates the risk is also associated with conventional antipsychotics. Antipsychotics are not indicated for the treatment of dementia-related psychosis. The prescribing information for all antipsychotic drugs will now include the same information about this risk in a BOXED WARNING and the WARNINGS section. For more information visit the FDA website at: [Web], [Web] and [Web].

What is this medicine?

PIMOZIDE (PI moe zide) helps to reduce the muscle and speech tics that are caused by Tourette's syndrome.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • dementia
  • heart disease
  • kidney disease
  • liver disease
  • Parkinson's disease
  • an unusual or allergic reaction to pimozide, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on the advice of your doctor or health care professional.

Talk to your pediatrician regarding the use of this medicine in children. While this medicine may be prescribed for children as young as 12 years of age for selected conditions, precautions do apply.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • aprepitant
  • arsenic trioxide
  • certain macrolide antibiotics like clarithromycin, dirithromycin, erythromycin
  • chloroquine
  • cimetidine
  • cisapride
  • clozapine
  • conivaptan
  • cyclobenzaprine
  • dalfopristin; quinupristin
  • diltiazem
  • droperidol
  • grapefruit juice
  • haloperidol
  • halothane
  • imatinib
  • isoniazid
  • levomethadyl
  • local anesthetics
  • maprotiline
  • medicines for fungal infections like ketoconazole, itraconazole, posaconazole, and voriconazole
  • medicines used to treat ADHD like amphetamine, dexmethylphenidate, dextroamphetamine, methylphenidate
  • methadone
  • mifepristone
  • nicardipine
  • pemoline
  • pentamidine
  • phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine
  • quinine
  • ranolazine
  • sodium phosphates
  • some medicines for HIV
  • some medicines for treating heart-rhythm problems
  • some medicines for treating depression or other mental illness such as citalopram, escitalopram, paroxetine, sertraline, fluvoxamine, and nefazodone
  • some quinolone antibiotics
  • tacrolimus
  • telithromycin
  • vardenafil
  • verapamil
  • zafirlukast
  • zileuton
  • ziprasidone

This medicine may also interact with the following medications:

  • barbiturates, like phenobarbital
  • bosentan
  • carbamazepine
  • ciprofloxacin
  • enoxacin
  • isoniazid (INH)
  • levodopa
  • medicines for sleep or anxiety
  • medicines for treating seizures
  • norfloxacin
  • pain relievers
  • rifampin
  • some medicines for treating asthma
  • some medicines for treating pain
  • tacrine

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. It may be several weeks before you see the full effects of this medicine. Do not stop taking this medicine suddenly. You may need to gradually reduce the dose. Only stop taking this medicine on advice of your doctor or health care professional.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can increase dizziness and drowsiness. Avoid alcoholic drinks.

Do not drink grapefruit juice products while taking this medicine. This can increase the chance of developing serious heart problems.

This medicine can reduce the response of your body to heat or cold. Dress warm in cold weather and stay hydrated in hot weather. If possible, avoid extreme temperatures like saunas, hot tubs, very hot or cold showers, or activities that can cause dehydration such as vigorous exercise.


Last Updated: May 07, 2013
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