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Phytonadione Solution for injection

This medicine is used to treat vitamin K deficiency or bleeding problems caused by various disorders

Generic Name: phytonadione  |  Brand Name: Konakion

Brand Names: Konakion, Aquamephyton, Mephyton

There is an FDA Alert for this drug. Click here to view it.

    IV and IM Administration
  • Severe hypersensitivity reactions, including fatal anaphlaxis, have occurred during and immediately after IV or IM injection of phytonadione injection.
  • Such severe reactions have occurred despite employing measures to prevent hypersensitivity reactions, including dilution of the injection and administration by slow infusion.
  • These severe reactions are consistent with hypersensitivity or anaphylaxis, including shock and cardiac and/or respiratory arrest and have occurred after initial administration.
  • Restrict IV and IM administration to those situations where sub-Q administration is not feasible and the serious risk associated with IV or IM administration is considered justified.

What is this medicine?

PHYTONADIONE (fye toe na DYE one) is a man-made form of vitamin K. This medicine is used to treat vitamin K deficiency or bleeding problems caused by various disorders. This medicine is also given to newborn babies to prevent bleeding.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • liver disease
  • an unusual or allergic reaction to phytonadione, other medicine, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This medicine is for injection under the skin, into a muscle, or rarely, into a vein. It is usually given by a health care professional in a hospital or clinic setting. In newborn babies, this medicine is injected into the muscle as a one-time dose shortly after they are born.

If you get this medicine at home, you will be taught how to prepare and give this medicine. Use exactly as directed. Take your medicine at regular intervals. Do not take your medicine more often than directed.

It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or healthcare provider to get one.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as newborns for selected conditions, precautions do apply.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

  • medicines that treat or prevent blood clots like warfarin

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. Your doctor or health care professional will schedule tests to make sure the medicine is working properly.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • bluish discoloration of lips, fingernails, or palms of hands
  • breathing problems
  • increased sweating
  • yellowing of the eyes or skin when this medicine is given to newborn babies

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • changes in taste
  • dizziness
  • flushing of the face
  • pain, inflammation, or swelling at site where injected

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Do not freeze. Protect from light. Store in tightly closed container and original carton until contents have been used. Throw away any unused medicine after the expiration date.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Last Updated: March 29, 2010
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