Drugs A - Z

Phendimetrazine Tartrate Oral tablet

It is used with a reduced calorie diet and exercise to help you lose weight

Generic Name: phendimetrazine  |  Brand Name: Obezine

What is this medicine?

PHENDIMETRAZINE (fen dye MET ra zeen) decreases your appetite. It is used with a reduced calorie diet and exercise to help you lose weight.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • agitation or nervousness
  • diabetes
  • glaucoma
  • heart disease
  • high blood pressure
  • history of substance abuse
  • kidney disease
  • lung disease called Primary Pulmonary Hypertension (PPH)
  • taken an MAOI like Carbex, Eldepryl, Marplan, Nardil, or Parnate in last 14 days
  • thyroid disease
  • an unusual or allergic reaction to phendimetrazine, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take this medicine at least 1 hour before eating. Do not take your medicine more often than directed. Do not suddenly stop taking your medicine because you may develop a severe reaction. Your doctor will tell you how much medicine to take. If your doctor wants you to stop the medicine, the dose will be slowly lowered over time to avoid any side effects.

Talk to your pediatrician regarding the use of this medicine in children. While this medicine may be prescribed for children as young as 12 years of age for selected conditions, precautions do apply.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
  • medicines for colds or breathing difficulties like pseudoephedrine or phenylephrine
  • procarbazine
  • sibutramine
  • stimulants like dexmethylphenidate, methylphenidate or modafinil

This medicine may also interact with the following medications:

  • medicines for diabetes
  • medicines for high blood pressure

What should I watch for while using this medicine?

Notify your physician immediately if you become short of breath while doing your normal activities.

Do not take this medicine within 6 hours of bedtime. It can keep you from getting to sleep. Avoid drinks that contain caffeine and try to stick to a regular bedtime every night.

This medicine was intended to be used in addition to a healthy diet and exercise. The best results are achieved this way. This medicine is only indicated for short-term use. Eventually your weight loss may level out. At that point, the drug will only help you maintain your new weight. Do not increase or in any way change your dose without consulting your doctor.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may increase dizziness and drowsiness. Avoid alcoholic drinks.


Last Updated: February 29, 2012
Licensed from
The Healthline Site, its content, such as text, graphics, images, search results, HealthMaps, Trust Marks, and other material contained on the Healthline Site ("Content"), its services, and any information or material posted on the Healthline Site by third parties are provided for informational purposes only. None of the foregoing is a substitute for professional medical advice, examination, diagnosis, or treatment. Always seek the advice of a physician or other qualified healthcare provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on the Healthline Site. If you think you may have a medical emergency, call your doctor or 911 immediately. Please read the Terms of Service for more information regarding use of the Healthline Site.
Advertisement