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Pazopanib Oral tablet

It is a biologic drug used to treat kidney cancer and sarcoma.

Generic Name: pazopanib

Brand Names: Votrient

What is this medicine?

PAZOPANIB is a biologic drug used to treat kidney cancer and sarcoma.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • bleeding problems
  • have had recent surgery (within 7 days) or are having surgery
  • heart disease
  • high blood pressure
  • history of stroke
  • liver disease
  • protein in your urine
  • stomach or intestine problems
  • thyroid problems
  • an unusual or allergic reaction to pazopanib, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Do not cut, crush or chew this medicine. Take this medicine on an empty stomach, at least 1 hour before or 2 hours after meals. Do not take with food. Do not take with grapefruit juice. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you've taken too much of this medicine contact a poison control center or emergency room at once.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If your next dose is to be taken in less than 12 hours, then do not take the missed dose. Take the next dose at your regular time. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medication with any of the following medications:
  • rifampin

This medicine may also interact with the following medications:

  • clarithromycin
  • dextromethorphan
  • grapefruit or grapefruit juice
  • ketoconazole
  • lapatinib
  • certain medicines for irregular heart beat like amiodarone, bepridil, dofetilide, encainide, flecainide, propafenone, quinidine
  • midazolam
  • paclitaxel
  • ritonavir

What should I watch for while using this medicine?

Visit your doctor for regular check ups. You will need to have blood work while you are taking this medicine.

This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

Be careful brushing and flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medicine.

Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.

Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information.

If you are going to have surgery or any other procedures, tell your doctor you are taking this medicine.


Last Updated: August 20, 2013
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