Drugs A - Z
Paliperidone Oral tablet, extended release
Generic Name: paliperidone
Brand Names: Invega
What is this medicine?PALIPERIDONE (pal ee PER i done) is used to treat schizophrenia and schizoaffective disorder.
What should I tell my health care provider before I take this medicine?They need to know if you have any of these conditions:
- chronic constipation or diarrhea
- diabetes or family history of diabetes
- history of stroke
- irregular heartbeat or low blood pressure
- kidney disease
- liver disease
- stomach problems like adhesions, bowel disease, short gut, trouble swallowing
- an unusual or allergic reaction to paliperidone, risperidone, other medicines, foods, dyes, or preservatives
- pregnant or trying to get pregnant
How should I use this medicine?Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Do not chew, crush, or cut the tablets. You can take this medicine with or without food. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your prescriber's advice.
A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.
Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 12 years old for selected conditions, precautions do apply.
What if I miss a dose?If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
What may interact with this medicine?Do not take this medicine with any of the following medications:
- some phenothiazines like chlorpromazine, mesoridazine, thioridazine
This medicine may also interact with the following medications:
- antibiotics like clarithromycin, erythromycin, gemifloxacin, levofloxacin
- daunorubicin, doxorubicin
- levodopa and other medications for Parkinson's disease
- local anesthetics
- medicines for anxiety, depression or psychotic disturbances
- medicines for blood pressure
- medicines for irregular heartbeat
- medicines for sleep
- medicines for treating seizures
- other medicines for schizophrenia
- prescription pain medications
- St. John's Wort
What should I watch for while using this medicine?Visit your doctor or health care professional for regular checks on your progress. It may be several weeks before you see the full effects. Do not suddenly stop taking this medicine. You may need to gradually reduce the dose. Only stop taking this medicine on the advice of your doctor or health care professional.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.
This medicine can reduce the response of your body to heat or cold. Dress warm in cold weather and stay hydrated in hot weather. If possible, avoid extreme temperatures like saunas, hot tubs, very hot or cold showers, or activities that can cause dehydration such as vigorous exercise.
The tablet shell for some brands of this medicine does not dissolve. This is normal. The tablet shell may appear whole in the stool. This is not a cause for concern.
What side effects may I notice from receiving this medicine?Side effects that you should report to your doctor or health care professional as soon as possible:
- allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
- change in blood sugar
- changes in vision
- dark urine
- fast or irregular heartbeat
- feeling faint or lightheaded, falls
- fever or chills, sore throat
- increased thirst or hunger
- inner restlessness, unable to keep still
- men: prolonged or painful erection
- muscle pain, stiffness
- trouble passing urine or change in the amount of urine
- unusual movements, spasms, tremor
- unusual decrease in sweating
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
- change in sex drive or performance
- dry mouth
- menstrual irregularity
- more or less saliva than normal
- stomach upset
- weight gain
Where should I keep my medicine?Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from moisture. Throw away any unused medicine after the expiration date.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.