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Oxymorphone Hydrochloride Oral tablet, extended release

It is used to treat moderate to severe pain that lasts for more than a few days

Generic Name: oxymorphone

Brand Names: Opana, Opana ER

There is an FDA Alert for this drug. Click here to view it.

What is this medicine?

OXYMORPHINE (ox i MOR feen) is a pain reliever. It is used to treat moderate to severe pain that lasts for more than a few days. It is used by people who have been taking an opioid or narcotic pain medicine.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • brain tumor
  • drug abuse or addiction
  • head injury
  • heart disease
  • if you frequently drink alcohol-containing drinks
  • intestinal disease
  • kidney disease
  • kyphoscoliosis
  • liver disease
  • lung disease, asthma, or breathing problems
  • seizures
  • an unusual or allergic reaction to oxymorphone, codeine, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a full glass of water. Follow the directions on the prescription label. Swallow only one tablet at a time. Do not wet, soak, or lick the tablet before you take it. Do not break, crush, or chew this medicine. Do not take broken tablets. Taking broken, chewed, crushed or dissolved tablets can be very dangerous. You may get too much medicine, too fast. Take this medicine on an empty stomach, at least 1 hour before or 2 hours after food. Do not take with food. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Patients over 65 years old may have a stronger reaction and need a smaller dose.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • alcohol or any product that contains alcohol

This medicine may also interact with the following medications:

  • antihistamines for allergy, cough and cold
  • atropine
  • benzodiazepines
  • certain medicines for bladder problems like oxybutynin, tolterodine
  • certain medicines for Parkinson's disease like benztropine, trihexyphenidyl
  • certain medicines for stomach problems like dicyclomine, hyoscyamine
  • certain medicines for travel sickness like scopolamine
  • ipratropium
  • medicines for depression, anxiety, or psychotic disturbances
  • medicines for sleep
  • muscle relaxants
  • naltrexone
  • narcotic medicines (opiates) for pain
  • phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine


Last Updated: August 23, 2012
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