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Nefazodone Hydrochloride Oral tablet

It is used to treat depression.

Generic Name: nefazodone

Brand Names: Serzone

There is an FDA Alert for this drug. Click here to view it.

    Hepatic Effects
  • Severe, life-threatening, sometimes fatal hepatic failure reported. (See Hepatic Effects under Cautions.)
  • Avoid use in patients with active liver disease or elevated serum transaminase concentrations.
  • Discontinue and do not reinitiate therapy in patients who develop evidence of hepatocellular injury (e.g., AST or ALT concentrations ≥3 times the ULN).
  • Antidepressants may increase risk of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults (18–24 years of age) with major depressive disorder and other psychiatric disorders; balance this risk with clinical need. Nefazodone is not approved for use in pediatric patients. (See Pediatric Use under Cautions.)
  • In pooled data analyses, risk of suicidality was not increased in adults >24 years of age and apparently was reduced in adults ≥65 years of age with antidepressant therapy compared with placebo.
  • Depression and certain other psychiatric disorders are themselves associated with an increased risk of suicide.
  • Appropriately monitor and closely observe all patients who are started on nefazodone therapy for clinical worsening, suicidality, or unusual changes in behavior; involve family members and/or caregivers in this process. (See Worsening of Depression and Suicidality Risk under Cautions.)

What is this medicine?

NEFAZODONE (nef AY zoe done) is used to treat depression.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • attempted suicide or thinking about it
  • bipolar disorder or mania
  • heart disease, previous heart attack or stroke
  • liver disease or a history of liver disease
  • seizures
  • an unusual or allergic reaction to nefazodone, other medicines, food, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. You may take this medicine with or without food. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not stop taking this medicine suddenly except upon the advice of your doctor. Stopping this medicine too quickly may cause serious side effects or your condition may worsen.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • carbamazepine
  • cisapride
  • duloxetine
  • eplerenone
  • ergot alkaloids like dihydroergotamine, ergotamine, methysergide
  • linezolid
  • lovastatin
  • medicines called MAO Inhibitors like Nardil, Parnate, Marplan, Eldepryl
  • methylene blue
  • pimozide
  • ranolazine
  • simvastatin
  • SSRIs like citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline
  • trazodone
  • triazolam
  • venlafaxine
  • red yeast rice

This medicine may also interact with the following medications:

  • atorvastatin
  • buspirone
  • cyclosporine
  • desipramine
  • digoxin
  • erythromycin
  • general anesthetics
  • haloperidol
  • ketoconazole
  • lithium
  • medicines for anxiety or sleeping problems, such as alprazolam, diazepam, or clonazepam
  • phenytoin
  • tacrolimus
  • warfarin

What should I watch for while using this medicine?

Tell your doctor if your symptoms do not get better or if they get worse. Visit your doctor or health care professional for regular checks on your progress. Because it may take several weeks to see the full effects of this medicine, it is important to continue your treatment as prescribed by your doctor.

Patients and their families should watch out for new or worsening thoughts of suicide or depression. Also watch out for sudden changes in feelings such as feeling anxious, agitated, panicky, irritable, hostile, aggressive, impulsive, severely restless, overly excited and hyperactive, or not being able to sleep. If this happens, especially at the beginning of treatment or after a change in dose, call your health care professional.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water will help. Contact your doctor if the problem does not go away or is severe.

Last Updated: May 06, 2013
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