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Naproxen Sodium, Pseudoephedrine Hydrochloride Oral tablet

An upper respiratory combination - It is used to treat the aches, pains, and congestion of a cold

Generic Name: naproxen-pseudoephedrine

Brand Names: Aleve-D Cold and Sinus, Aleve Sinus & Headache, Aleve Cold and Sinus

What is this medicine?

NAPROXEN; PSEUDOEPHEDRINE (na PROX en; soo doe e FED rin) is a combination of pain reliever and a decongestant. It is used to treat the aches, pains, and congestion of a cold. This medicine will not treat an infection.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

How should I use this medicine?

Take this medicine by mouth with a full glass of water. Follow the directions on the prescription label. You can take it with or without food. If it upsets your stomach, take it with food. Do not cut, crush or chew this medicine. Take your medicine at regular intervals. Do not take it more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 12 years old for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

This medicine may also interact with the following medications:

  • alcohol
  • alendronate
  • aspirin and aspirin-like medicines
  • atomoxetine
  • bretylium
  • cyclopropane
  • digoxin
  • dyphylline
  • flavocoxid
  • furazolidone
  • ginkgo, Ginkgo biloba
  • medicines for sleep during surgery
  • linezolid
  • medicines for blood pressure, chest pain, heart disease, irregular heart beat
  • medicines for depression, anxiety, or psychotic disturbances
  • medicines that treat or prevent blood clots like warfarin
  • NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
  • other medicines for allergy, cough, cold, fever or pain
  • other medicine that contains naproxen or pseudoephedrine
  • pamidronate
  • probenecid
  • procarbazine
  • St. John's Wort

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.


Last Updated: July 13, 2009
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