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Muromonab-CD3 (Murine) Solution for injection

It is used to treat rejection of a kidney transplant.

Generic Name: muromonab-CD3

Brand Names: Orthoclone OKT3

What is this medicine?

MUROMONAB-CD3 (myoo roe MOE nab CD3) is used to treat rejection of a kidney transplant.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • angina
  • fever
  • fluid overload, sudden weight gain
  • heart disease
  • high blood pressure
  • lung disease
  • previous treatment with muromonab
  • seizure condition
  • an unusual or allergic reaction to muromonab, murine, mice, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This medicine is for injection into a vein. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for selected conditions, precautions do apply.

What if I miss a dose?

This does not apply.

What may interact with this medicine?

  • azathioprine
  • cyclosporine
  • hormones such as prednisone or cortisone
  • indomethacin
  • some vaccines

What should I watch for while using this medicine?

Your condition will be monitored carefully while you are receiving this medicine. You will need regular blood work while you are taking this medicine. Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.

Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information.

This medicine may decrease your body's ability to fight infection. Avoid being around people who are sick. Do not get any vaccinations without your doctor's approval.

This medicine may increase your risk of getting cancer. Talk to your doctor about the benefits and risks of taking this medicine.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • breathing problems
  • bruising, pinpoint red spots on the skin
  • chest pain
  • confusion
  • extreme changes in behavior or mood
  • eyes sensitive to light
  • fast, irregular heartbeat
  • fever, chills, or any other sign of infection
  • pain, tingling, numbness in the hands or feet
  • seizures
  • stiff neck
  • swelling of the ankles, feet, hands
  • trouble passing urine or change in the amount of urine
  • unusually high or low blood pressure
  • unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • diarrhea
  • dizziness
  • ear or nose congestion
  • headache
  • nausea, vomiting
  • pain, redness at site where injected
  • stomach upset
  • trembling

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.


Last Updated: July 06, 2009
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