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Methylergonovine Maleate Solution for injection

It is used to contract the uterus at the end of child birth

Generic Name: methylergonovine  |  Brand Name: Methergine

Brand Names: Methergine

What is this medicine?

METHYLERGONOVINE (meth il er goe NOE veen) is one of a group of medicines known as ergot alkaloids. It is used to contract the uterus at the end of child birth. It is also used to prevent or to treat excessive bleeding after child birth.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • high blood pressure
  • infection
  • kidney disease
  • liver disease
  • an unusual or allergic reaction to methylergonovine, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This medicine is for injection into a muscle or infusion into a vein. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

This does not apply.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • certain antibiotics like clarithromycin, erythromycin, or troleandomycin
  • cocaine
  • grapefruit juice
  • imatinib
  • medicines for colds, flu, or breathing difficulties
  • medicines for fungal infections like itraconazole, ketoconazole, posaconazole, and voriconazole
  • medicines used to induce labor
  • medicines used to treat migraines like almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, or zolmitriptan
  • midodrine
  • nefazodone
  • other ergot alkaloids like ergotamine, dihydroergotamine, ergonovine, or methysergide
  • some medicines for high blood pressure or chest pain
  • some medicines for the treatment of HIV infection or AIDS

This medicine may also interact with the following medications:

  • clotrimazole
  • fluconazole
  • fluoxetine
  • fluvoxamine
  • zileuton

What should I watch for while using this medicine?

See your doctor for a follow up visit as directed.

Do not use tampons, have sex, or use douches until the bleeding has stopped and your doctor allows you to return to normal activities.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • breathing problems
  • chest pain or tightness
  • confusion
  • fast, slow, or pounding heartbeat
  • fever or chills
  • hallucinations
  • increased bleeding
  • leg or arm pain or cramps
  • passing tissue or large clots
  • seizures
  • swelling of hands, ankles, or feet
  • tingling, pain or numbness in feet or hands
  • vomiting
  • unusually tired or weak

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • change in taste
  • diarrhea
  • headache
  • nausea
  • stomach cramps
  • temporary ringing of ears

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.


Last Updated: June 25, 2009
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