Drugs A - Z

Saxagliptin, Metformin Hydrochloride Oral tablet, extended release

This medicine lowers blood sugar

Generic Name: Kombiglyze XR

What is this medicine?

METFORMIN; SAXAGLIPTIN (met FOR min; SAX a glip tin) is a combination of 2 medicines used to treat type 2 diabetes. This medicine lowers blood sugar. Treatment is combined with a balanced diet and exercise.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • become easily dehydrated
  • diabetic ketoacidosis
  • gallstones
  • heart disease
  • high levels of triglyceride in the blood
  • history of alcohol abuse problem
  • history of pancreatitis
  • if you often drink alcohol
  • kidney disease
  • liver disease
  • low levels of vitamin B12 in the blood
  • older than 80 years
  • polycystic ovary syndrome
  • serious infection or injury
  • thyroid disease
  • type 1 diabetes
  • an unusual or allergic reaction to metformin, saxagliptin, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take this medicine with the evening meal. Do not cut, crush or chew this medicine. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you've taken too much of this medicine contact a poison control center or emergency room at once.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • certain contrast medicines given before X-rays, CT scans, MRI, or other procedures
  • dofetilide
  • gatifloxacin

This medicine may also interact with the following medications:

  • amiloride
  • antiviral medicines for HIV or AIDS
  • calcium channel blockers
  • certain antibiotics like clarithromycin and telithromycin
  • certain medicines for fungal infections like ketoconazole and itraconazole
  • cimetidine
  • digoxin
  • diuretics
  • female hormones, like estrogens or progestins and birth control pills
  • isoniazid
  • medicines for diabetes
  • morphine
  • nefazodone
  • niacin, niacinamide
  • phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine
  • phenytoin
  • procainamide
  • quinidine
  • quinine
  • ranitidine
  • steroid medicines like prednisone or cortisone
  • stimulant medicines for attention disorders, weight loss, or to stay awake
  • thyroid medicines
  • trimethoprim
  • vancomycin

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress.

Learn how to check your blood sugar. Learn the symptoms of high or low blood sugar and how to manage them.

If you have low blood sugar, eat or drink something that has sugar. Make sure others know to get medical help quickly if you have serious symptoms of low blood sugar, like if you become unconscious or have a seizure.

If you need surgery or if you will need a procedure with contrast drugs, tell your doctor or health care professional that you are taking this medicine.

Wear a medical identification bracelet or chain to say you have diabetes, and carry a card that lists all your medications.


Last Updated: August 29, 2013
Licensed from
The Healthline Site, its content, such as text, graphics, images, search results, HealthMaps, Trust Marks, and other material contained on the Healthline Site ("Content"), its services, and any information or material posted on the Healthline Site by third parties are provided for informational purposes only. None of the foregoing is a substitute for professional medical advice, examination, diagnosis, or treatment. Always seek the advice of a physician or other qualified healthcare provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on the Healthline Site. If you think you may have a medical emergency, call your doctor or 911 immediately. Please read the Terms of Service for more information regarding use of the Healthline Site.
Advertisement