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Pioglitazone Hydrochloride, Metformin Hydrochloride Oral tablet, extended release

It helps to control blood sugar

Generic Name: Actoplus Met XR

What is this medicine?

METFORMIN; PIOGLITAZONE (met FOR min; pye oh GLI ta zone) helps to treat type 2 diabetes. It helps to control blood sugar. Treatment is combined with diet and exercise.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • bladder cancer
  • become easily dehydrated
  • diabetic ketoacidosis
  • heart disease
  • if you frequently drink alcohol containing drinks
  • kidney disease
  • liver disease
  • polycystic ovary syndrome
  • serious infection or injury
  • swelling of the arms, legs, or feet
  • undergoing surgery or certain x-ray procedures with injectable contrast agents
  • vomiting
  • an unusual or allergic reaction to metformin, pioglitazone, medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take this medicine with food. Swallow whole, do not crush or chew. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you've taken too much of this medicine contact a poison control center or emergency room at once.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • dofetilide
  • certain contrast medicines given before X-rays, CT scans, MRI, or other procedures
  • gatifloxacin

This medicine may also interact with the following medications:

  • digoxin
  • diuretics
  • female hormones, like estrogens or progestins and birth control pills
  • isoniazid
  • medicines for blood pressure, heart disease, irregular heart beat
  • morphine
  • nicotinic acid
  • phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine
  • phenytoin
  • procainamide
  • quinidine
  • quinine
  • ranitidine
  • steroid medicines like prednisone or cortisone
  • stimulant medicines for attention disorders, weight loss, or to stay awake
  • thyroid medicines
  • trimethoprim
  • vancomycin

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress.

Learn how to check your blood sugar. Learn the symptoms of low and high blood sugar and how to manage them.

If you have low blood sugar, eat or drink something that has sugar. Make sure others know to get medical help quickly if you have serious symptoms of low blood sugar, like if you become unconscious or have a seizure

The tablet shell for some brands of this medicine does not dissolve. This is normal. The tablet shell may appear whole in the stool. This is not a cause for concern.

If you need surgery or if you will need a procedure with contrast drugs, tell your doctor or health care professional that you are taking this medicine.

Wear a medical identification bracelet or chain to say you have diabetes, and carry a card that lists all your medications.


Last Updated: August 08, 2011
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