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Meperidine Hydrochloride, Promethazine Hydrochloride Oral capsule

It is used to treat moderate to severe pain

Generic Name: meperidine-promethazine

Brand Names: Mepergan Fortis, Meprozine, Meperidine HCl-Promethazine HCl

What is this medicine?

MEPERIDINE; PROMETHAZINE (me PER i deen; proe METH a zeen) is a pain reliever. It is used to treat moderate to severe pain.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • brain tumor
  • head injury
  • heart disease
  • kidney disease
  • liver disease
  • lung disease or breathing difficulties, including asthma
  • seizures
  • use within 14 days of a MAOI like Carbex, Eldepryl, Marplan, Nardil, and Parnate
  • an unusual or allergic reaction to meperidine or other opiate drugs, promethazine or other phenothiazines, lactose, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a full glass of water. Follow the directions on the prescription label. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not suddenly stop taking your medicine because you may develop a severe reaction. Your body becomes used to the medicine. This does NOT mean you are addicted. Addiction is a behavior related to getting and using a drug for a non-medical reason. If you have pain, you have a medical reason to take pain medicine. Your doctor will tell you how much medicine to take. If your doctor wants you to stop the medicine, the dose will be slowly lowered over time to avoid any side effects.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Patients over 65 years old may have a stronger reaction and need a smaller dose.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • amoxapine
  • disopyramide
  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
  • maprotiline
  • procarbazine
  • risperidone
  • ritonavir
  • trimethobenzamide

This medicine may also interact with the following medications:

  • alcohol or medicines that contain alcohol
  • antihistamines
  • barbiturates like phenobarbital
  • general anesthetics
  • medicines for depression, anxiety, or psychotic disturbances
  • medicines for pain
  • medicines for sleep
  • muscle relaxants
  • naltrexone
  • phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine

What should I watch for while using this medicine?

Tell your doctor or health care professional if your pain does not go away, if it gets worse, or if you have new or a different type of pain. You may develop tolerance to the medicine. Tolerance means that you will need a higher dose of the medicine for pain relief. Tolerance is normal and is expected if you take the medicine for a long time.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.

This medicine may cause dry eyes and blurred vision. If you wear contact lenses you may feel some discomfort. Lubricating drops may help. See your eye doctor if the problem does not go away or is severe.

The medicine will cause constipation. Try to have a bowel movement at least every 2 to 3 days. If you do not have a bowel movement for 3 days, call your doctor or health care professional.


Last Updated: July 07, 2009
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