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Medroxyprogesterone Acetate Suspension for injection [Malignancy]

It is used to treat the symptoms of endometrial and renal cancer

Generic Name: medroxyprogesterone injection  |  Brand Name: Depo-Provera Contraceptive

Brand Names: Depo-Subq Provera 104, Depo-Provera Contraceptive, Depo-Provera

There is an FDA Alert for this drug. Click here to view it.

    Bone Mineral Density
  • Use of parenteral medroxyprogesterone preparations (i.e., Depo-Provera® Contraceptive, depo-subQ provera 104®, or medroxyprogesterone acetate contraceptive injection) may result in loss of bone mineral density (BMD). Bone loss is greater with increasing duration of therapy and may not be completely reversible.
  • Not known whether use of these parenteral preparations in young women (e.g., during adolescence, early adulthood) will reduce peak bone mass and increase risk of osteoporotic fractures later in life. Loss of BMD is of particular concern during adolescence and early adulthood, a critical period of bone accretion.
  • Use parenteral medroxyprogesterone for long-term contraception (e.g., >2 years) only if other contraceptive methods are inadequate.

What is this medicine?

MEDROXYPROGESTERONE (me DROX ee proe JES te rone) is a man-made hormone. It is used to treat the symptoms of endometrial and renal cancer.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • blood vessel disease
  • breast cancer
  • history of a blood clot in the lungs or legs
  • liver disease
  • mental depression
  • migraine
  • seizures
  • stroke
  • vaginal bleeding
  • an unusual or allergic reaction to medroxyprogesterone, other hormones, medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This medicine is for injection into a muscle. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

It is important not to miss your dose. Call your doctor or health care professional if you are unable to keep an appointment.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • bosentan

This medicine may also interact with the following medications:

  • aminoglutethimide
  • antibiotics or medicines for infections, especially rifampin, rifabutin, rifapentine, and griseofulvin
  • aprepitant
  • barbiturate medicines such as phenobarbital or primidone
  • bexarotene
  • carbamazepine
  • medicines for seizures like ethotoin, felbamate, oxcarbazepine, phenytoin, topiramate
  • modafinil
  • St. John's wort

What should I watch for while using this medicine?

Your condition will be monitored carefully while you are receiving this medicine.

Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • breast tenderness or discharge
  • breathing problems
  • changes in vision
  • depression
  • feeling faint or lightheaded, falls
  • fever
  • pain in the abdomen, chest, groin, or leg
  • problems with balance, talking, walking
  • unusually weak or tired
  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • fluid retention, swelling
  • headache
  • irregular periods, spotting, or absent periods
  • irritation at site where injected
  • nausea
  • trouble sleeping
  • weight gain or loss

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Last Updated: December 16, 2009
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Medroxyprogesterone injection