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Drug Notebook

FDA Alerts

    Bone Mineral Density
  • Use of parenteral medroxyprogesterone preparations (i.e., Depo-Provera® Contraceptive, depo-subQ provera 104®, or medroxyprogesterone acetate contraceptive injection) may result in loss of bone mineral density (BMD). Bone loss is greater with increasing duration of therapy and may not be completely reversible.
  • Not known whether use of these parenteral preparations in young women (e.g., during adolescence, early adulthood) will reduce peak bone mass and increase risk of osteoporotic fractures later in life. Loss of BMD is of particular concern during adolescence and early adulthood, a critical period of bone accretion.
  • Use parenteral medroxyprogesterone for long-term contraception (e.g., >2 years) only if other contraceptive methods are inadequate.

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medroxyPROGESTERone
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What is this medicine?

MEDROXYPROGESTERONE is a hormone in a class called progestins. It is commonly used to prevent the uterine lining from overgrowth in women taking an estrogen after menopause. It is also used to treat irregular menstrual bleeding or a lack of menstrual bleeding in women. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • blood vessel disease or a history of a blood clot in the lungs or legs
  • breast, cervical or vaginal cancer
  • heart disease
  • kidney disease
  • liver disease
  • migraine
  • recent miscarriage or abortion
  • mental depression
  • migraine
  • seizures (convulsions)
  • stroke
  • vaginal bleeding that has not been evaluated
  • an unusual or allergic reaction to medroxyprogesterone, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take your doses at regular intervals. Do not take your medicine more often than directed. A patient information sheet for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently. Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed. While this drug may be prescribed for children as young as 13 years for selected conditions, precautions do apply. Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your health care professional for regular checks on your progress. You will need a regular breast and pelvic exam. If you have any reason to think you are pregnant, stop taking this medicine at once and contact your doctor or health care professional.

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