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Leuprolide Acetate Implant

It is a man-made protein that acts like a natural hormone in the body

Generic Name: leuprolide  |  Brand Name: Eligard

Brand Names: Lupron Depot-Gyn, Viadur, Lupron, Lupron Depot-Ped, Eligard, Lupron Depot

There is an FDA Alert for this drug. Click here to view it.

What is this medicine?

LEUPROLIDE (loo PROE lide) is a man-made protein that acts like a natural hormone in the body. It decreases testosterone in men and decreases estrogen in women. In men, this medicine is used to treat advanced prostate cancer. In women, some forms of this medicine may be used to treat endometriosis, uterine fibroids, or other female hormone-related problems.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • diabetes
  • heart disease or previous heart attack
  • high blood pressure
  • high cholesterol
  • osteoporosis
  • pain or difficulty passing urine
  • spinal cord metastasis
  • stroke
  • tobacco smoker
  • unusual vaginal bleeding (women)
  • an unusual or allergic reaction to leuprolide, benzyl alcohol, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This medicine is for injection into a muscle or for implant or injection under the skin. It is given by a health care professional in a hospital or clinic setting. The specific product will determine how it will be given to you. Make sure you understand which product you receive and how often you will receive it.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

It is important not to miss a dose. Call your doctor or health care professional if you are unable to keep an appointment.

Depot injections: Depot injections are given either once-monthly, every 12 weeks, every 16 weeks, or every 24 weeks depending on the product you are prescribed. The product you are prescribed will be based on if you are male or female, and your condition. Make sure you understand your product and dosing.

Implant dosing: The implant is removed and replaced once a year. The implant is only used in males.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • chasteberry

This medicine may also interact with the following medications:

  • herbal or dietary supplements, like black cohosh or DHEA
  • female hormones, like estrogens or progestins and birth control pills, patches, rings, or injections
  • male hormones, like testosterone

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. During the first weeks of treatment, your symptoms may get worse, but then will improve as you continue your treatment. You may get hot flashes, increased bone pain, increased difficulty passing urine, or an aggravation of nerve symptoms. Discuss these effects with your doctor or health care professional, some of them may improve with continued use of this medicine.

Female patients may experience a menstrual cycle or spotting during the first months of therapy with this medicine. If this continues, contact your doctor or health care professional.


Last Updated: June 21, 2011
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