Drugs A - Z

Leucovorin Calcium Oral tablet

It is used to prevent or to treat the harmful effects of some medicines.

Generic Name: leucovorin

Brand Names: Leucovorin Calcium Novaplus

What is this medicine?

LEUCOVORIN (loo koe VOR in) is used to prevent or to treat the harmful effects of some medicines.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • anemia from low levels of vitamin B-12 in the blood
  • frequent vomiting and diarrhea
  • an unusual or allergic reaction to leucovorin, folic acid, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take your doses at regular intervals. Do not take your medicine more often than directed. It is very important to take this medicine exactly how it is prescribed. Do not stop taking except on your doctor's advice even if you feel better.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

  • capecitabine
  • fluorouracil
  • phenobarbital
  • phenytoin
  • primidone
  • trimethoprim-sulfamethoxazole

What should I watch for while using this medicine?

Your condition will be monitored carefully while you are receiving this medicine. You will need important blood work done while you are taking this medicine.

Tell your doctor if you have nausea or vomiting regularly.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • breathing problems

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 25 degrees C (59 and 77 degrees F). Protect from light and moisture. Throw away any unused medicine after the expiration date.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.


Last Updated: June 23, 2009
Licensed from
The Healthline Site, its content, such as text, graphics, images, search results, HealthMaps, Trust Marks, and other material contained on the Healthline Site ("Content"), its services, and any information or material posted on the Healthline Site by third parties are provided for informational purposes only. None of the foregoing is a substitute for professional medical advice, examination, diagnosis, or treatment. Always seek the advice of a physician or other qualified healthcare provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on the Healthline Site. If you think you may have a medical emergency, call your doctor or 911 immediately. Please read the Terms of Service for more information regarding use of the Healthline Site.
Advertisement