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Kanamycin Sulfate Solution for injection

It is used to treat certain kinds of bacterial infections

Generic Name: kanamycin  |  Brand Name: Kantrex

Brand Names: Kanamycin Sulfate, Kantrex

There is an FDA Alert for this drug. Click here to view it.

    Neurotoxicity and Ototoxicity
  • Neurotoxicity (manifested as both auditory and vestibular ototoxicity) can occur. Other neurotoxicity manifestations include vertigo, numbness, skin tingling, muscle twitching, and seizures.
  • Eighth-cranial nerve impairment develops principally in patients with preexisting renal damage and in those with normal renal function who receive doses higher or treatment longer than recommended.
  • Aminoglycoside-induced ototoxicity is irreversible, usually bilateral, and may be partial or total.
  • Risk of hearing loss increases with degree of exposure to either high peak or high trough serum concentrations.
  • Adjust dosage or discontinue kanamycin if evidence of ototoxicity (e.g., dizziness, vertigo, tinnitus, roaring in the ears, hearing loss) occurs.
  • Patients developing cochlear damage may not have symptoms during aminoglycoside treatment to warn them of eighth-cranial nerve toxicity and total or partial, irreversible, bilateral deafness may occur after drug discontinued.

    Nephrotoxicity
  • Potentially nephrotoxic.
  • Oliguria may indicate renal impairment.
  • Nephrotoxicity develops principally in patients with preexisting renal damage and in those with normal renal function who receive doses higher or treatment longer than recommended.

    Patient Monitoring
  • Patients should be under close clinical observation because of potential toxicities.
  • Closely monitor renal and eighth-cranial nerve function, especially in patients with known or suspected renal impairment at start of treatment and also in those whose renal function is initially normal but who develop renal dysfunction during treatment.
  • Periodically monitor serum kanamycin concentrations to ensure adequate concentrations and avoid potentially toxic and prolonged peak concentrations (>35 mcg/mL).
  • Rising trough concentrations (>10 mcg/mL) may indicate tissue accumulation. Tissue accumulation, excessive peak concentrations, cumulative dose, advanced age, and dehydration may contribute to ototoxicity and nephrotoxicity.
  • Evaluate urine for decreased specific gravity and increased excretion of protein, cells, and casts; periodically determine BUN, Scr, and CLcr.
  • When feasible, perform serial audiograms in patients old enough to be tested, particularly high-risk patients.
  • Discontinue kanamycin or adjust dosage if there is evidence of impaired renal, vestibular, or auditory function.

    Neuromuscular Blockade
  • Concomitant use of an aminoglycoside with anesthesia and muscle-relaxing drugs may cause neuromuscular blockade with respiratory paralysis. May occur with aminoglycosides given by any route, including intraperitoneal instillation.
  • Consider possibility of neuromuscular blockade and respiratory paralysis when administering aminoglycosides, especially concurrently with anesthetics or neuromuscular-blocking agents (e.g., tubocurarine, succinylcholine, decamethonium) or in patients receiving massive transfusions of citrate-anticoagulated blood. (See Interactions.)
  • Calcium salts may reduce neuromuscular blockade, but mechanical respiratory assistance may be necessary.

    Interactions
  • Avoid concurrent and/or sequential use of other neurotoxic or nephrotoxic drugs, particularly other aminoglycosides (including paromomycin), amphotericin B, bacitracin, cisplatin, colistimethate/colistin, polymyxin B, vancomycin, and viomycin. (See Interactions.)
  • Avoid concurrent use of potent diuretics (e.g., ethacrynic acid, furosemide, meralluride sodium [not commercially available in the US], sodium mercaptomerin [not commercially available in the US], mannitol) since diuretics themselves may cause ototoxicity and IV diuretics enhance toxicity by altering serum and tissue aminoglycoside concentrations. (See Interactions.)

What is this medicine?

KANAMYCIN (kan a MYE sin) is an aminoglycoside antibiotic. It is used to treat certain kinds of bacterial infections. It will not work for colds, flu, or other viral infections.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • balance problems
  • hearing problems
  • kidney disease
  • myasthenia gravis
  • Parkinson's disease
  • an unusual or allergic reaction to kanamycin, aminoglycosides sulfites, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This medicine is for injection into a muscle or infusion into a vein. It is usually given by a health care professional in a hospital or clinic setting.

If you get this medicine at home, you will be taught how to prepare and give this medicine. Use exactly as directed. Take your medicine at regular intervals. Do not take your medicine more often than directed. Take all of your medicine as directed even if you think you are better. Do not skip doses or stop your medicine early.

It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or healthcare provider to get one.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for selected conditions, precautions do apply.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • cidofovir

This medicine may also interact with the following medications:

  • anesthesia drugs
  • cisplatin
  • diuretics
  • muscle relaxers
  • other antibiotics

What should I watch for while using this medicine?

Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.

Tell your doctor or health care professional if you have any hearing problems.

Tell your doctor or health care professional if you have any problems passing urine.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • breathing problems
  • burning, numbness, tingling
  • changes in hearing
  • confused, dizzy, disoriented
  • fever
  • loss of balance
  • muscle twitching
  • redness, blistering, peeling or loosening of the skin, including inside the mouth
  • seizures
  • trouble passing urine or change in the amount or color of urine
  • unusual bleeding or bruising
  • unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • diarrhea
  • headache
  • nausea, vomiting
  • pain at site where injected

Where should I keep my medicine?

Keep out of the reach of children.

If you are using this medicine at home, you will be instructed on how to store this medicine. Throw away any unused medicine after the expiration date on the label.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.


Last Updated: June 19, 2009
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