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Drug Notebook

FDA Alerts

  • Itraconazole capsules should not be used for treatment of onychomycosis in patients with evidence of ventricular dysfunction, including CHF or history of CHF. Discontinue itraconazole if signs or symptoms of CHF occur. IV itraconazole has caused negative inotropic effects in healthy individuals and in dogs.
  • Concomitant use with cisapride, pimozide, quinidine, or dofetilide is contraindicated. Itraconazole is a potent inhibitor of CYP3A4 isoenzymes and may increase plasma concentrations of drugs metabolized by CYP3A4. Serious cardiovascular events, including QT prolongation, torsades de pointes, ventricular tachycardia, cardiac arrest, and/or sudden death have occurred in patients using cisapride, pimozide, or quinidine concomitantly with itraconazole and/or other CYP3A4 inhibitors. (See Interactions.)

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itraconazole
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(i tra KO na zole)

What is this medicine?

ITRACONAZOLE (i tra KO na zole) is an antifungal medicine. It is used to treat certain kinds of fungal or yeast infections.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

How should I use this medicine?

Take this medicine by mouth. Follow the directions on the prescription label. Use a specially marked spoon, or container to measure your dose. Ask your pharmacist if you do not have one. Household spoons are not accurate. Swish the solution in the mouth then swallow. Do not take with food. Take your medicine at regular intervals. Do not take your medicine more often than directed. Take all of your medicine as directed even if you think your are better. Do not skip doses or stop your medicine early.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

This medicine may also interact with the following medications:

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular check ups. Tell your doctor if your symptoms do not start to get better or if they get worse. Some fungal infections need many weeks or months of treatment to cure.

If you use antacids, do not take them at the same time as this medicine. Instead, take this medicine 1 hour before or 4 hours after antacids.


Last Updated: May 05, 2009
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