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Imipramine Hydrochloride Oral tablet

It is used to treat depression

Generic Name: imipramine  |  Brand Name: Tofranil-PM

Brand Names: Tofranil-PM, Tofranil

There is an FDA Alert for this drug. Click here to view it.

What is this medicine?

IMIPRAMINE (im IP ra meen) is used to treat depression. This medicine can also help children who have a nighttime bed wetting problem.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • an alcohol problem
  • asthma, difficulty breathing
  • bipolar disorder or schizophrenia
  • difficulty passing urine, prostate trouble
  • fast or irregular heart beat
  • glaucoma
  • heart disease or recent heart attack
  • kidney or liver disease
  • seizures
  • stroke
  • thoughts or plans of suicide, a previous suicide attempt, or family history of suicide attempt
  • thyroid disease
  • an unusual or allergic reaction to imipramine, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking this medicine suddenly except upon the advice of your doctor. Stopping this medicine too quickly may cause serious side effects or your condition may worsen.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed. While this drug may be prescribed for children as young as 6 years for selected conditions, precautions do apply.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • amoxapine
  • arsenic trioxide
  • certain medicines used to regulate abnormal heartbeat or to treat other heart conditions
  • cisapride
  • cocaine
  • grepafloxacin
  • halofantrine
  • levomethadyl
  • linezolid
  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
  • methylene blue (injected into a vein)
  • other medicines for mental depression
  • phenothiazines like perphenazine, thioridazine and chlorpromazine
  • pimozide
  • procarbazine
  • sparfloxacin
  • St. John's Wort
  • ziprasidone

This medicine may also interact with the following medications:

  • atropine and related drugs like hyoscyamine, scopolamine, tolterodine and others
  • barbiturate medicines for inducing sleep or treating seizures like phenobarbital
  • cimetidine
  • clonidine
  • local anesthetics
  • medicines for high blood pressure
  • prescription pain medications
  • seizure or epilepsy medicine such as carbamazepine or phenytoin
  • stimulants like dexmethylphenidate or methylphenidate
  • thyroid hormones


Last Updated: May 06, 2013
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