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Idarubicin Hydrochloride Solution for injection

This medicine is used to treat acute myeloid leukemia (AML)

Generic Name: idarubicin  |  Brand Name: Idamycin

Brand Names: Idamycin, Idamycin PFS

There is an FDA Alert for this drug. Click here to view it.

  • Severe local tissue necrosis if extravasation occurs. Do not administer IM or sub-Q. Administer slowly into the tubing of a freely flowing IV infusion. (See Administration under Dosage and Administration.)
  • Possible cardiotoxicity and potentially fatal CHF. Risk of cardiotoxicity is greater in patients who have preexisting cardiac disease or who have received prior therapy with anthracyclines or other cardiotoxic agents. (See Cardiac Effects under Cautions.)
  • Severe myelosuppression may occur. (See Hematologic Effects under Cautions.)
  • Administer only under supervision of qualified clinicians experienced in use of cytotoxic therapy. Appropriate management of complications is possible only when adequate diagnostic and treatment facilities are readily available. (See Adequate Patient Evaluation and Monitoring under Cautions.)
  • Dosage reduction should be considered in patients with hepatic or renal impairment. (See Special Populations under Dosage and Administration.)

What is this medicine?

IDARUBICIN (eye da RUE bi sin) is a chemotherapy drug. This medicine is used to treat acute myeloid leukemia (AML).

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • blood disorders
  • heart disease
  • infection (especially a virus infection such as chickenpox, cold sores, or herpes)
  • irregular heartbeat
  • kidney disease
  • liver disease
  • recent or ongoing radiation therapy
  • an unusual or allergic reaction to idarubicin, other chemotherapy agents, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This drug is given as an infusion into a vein. It is administered in a hospital or clinic by a specially trained health care professional. If you have pain, swelling, burning or any unusual feeling around the site of your injection, tell your health care professional right away.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

It is important not to miss your dose. Call your doctor or health care professional if you are unable to keep an appointment.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • cisapride
  • droperidol
  • halofantrine
  • pimozide

This medicine may also interact with the following medications:

  • chloroquine
  • chlorpromazine
  • clarithromycin
  • cyclophosphamide
  • cyclosporine
  • erythromycin
  • medicines for depression, anxiety, or psychotic disturbances
  • medicines for irregular heart beat
  • medicines for nausea, vomiting like dolasetron, ondansetron, palonosetron
  • medicines to increase blood counts like filgrastim, pegfilgrastim, sargramostim
  • methadone
  • pentamidine
  • prochlorperazine
  • vaccines

Talk to your doctor or health care professional before taking any of these medicines:

  • acetaminophen
  • aspirin
  • ibuprofen
  • ketoprofen
  • naproxen

What should I watch for while using this medicine?

Your condition will be monitored carefully while you are receiving this medicine. You will need important blood work done while you are taking this medicine.

This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

Your urine may turn orange-red for a few days after your dose. This is not blood. If your urine is dark or brown, call your doctor.

In some cases, you may be given additional medicines to help with side effects. Follow all directions for their use.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

Be careful brushing and flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medicine.

Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.

Do not become pregnant while taking this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.

Men may have a lower sperm count while taking this medicine. Talk to your doctor if you plan to father a child.


Last Updated: May 05, 2009
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