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Fluphenazine Decanoate Oil for injection

It is used to treat the symptoms of schizophrenia and other mental disorders

Generic Name: fluphenazine  |  Brand Name: Prolixin

Brand Names: Permitil, Prolixin Enanthate, Prolixin

There is an FDA Alert for this drug. Click here to view it.

What is this medicine?

FLUPHENAZINE (floo FEN a zeen) is used to treat the symptoms of schizophrenia and other mental disorders. Not all fluphenazine injections are the same. Do not change the brand you are using without checking with your doctor or health care professional.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • blood disorders or disease
  • dementia
  • head injury
  • heart disease
  • liver disease
  • Parkinson's disease
  • Reye's syndrome
  • uncontrollable movement disorder
  • an unusual or allergic reaction to fluphenazine, other medicines foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This medicine is for injection into a muscle or under the skin. It is given by a health-care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

This does not apply.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • amoxapine
  • certain antibiotics like gatifloxacin, grepafloxacin, sparfloxacin
  • cisapride
  • clozapine
  • dofetilide
  • droperidol
  • ephedrine
  • medicines for mental depression like escitalopram, fluoxetine, paroxetine, sertraline
  • ibutilide
  • levomethadyl
  • maprotiline
  • other phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, and thioridazine
  • pimozide
  • pindolol
  • propranolol
  • risperidone
  • sotalol
  • trimethobenzamide
  • ziprasidone

This medicine may also interact with the following medications:

  • atropine
  • some medications for high blood pressure or heart problems

What should I watch for while using this medicine?

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

This medicine can reduce the response of your body to heat or cold. Dress warm in cold weather and stay hydrated in hot weather. If possible, avoid extreme temperatures like saunas, hot tubs, very hot or cold showers, or activities that can cause dehydration such as vigorous exercise.

This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.

If you are going to have surgery, tell your doctor or health care professional that you are taking this medicine.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • blurred vision
  • breast enlargement in men or women
  • breast milk in women who are not breast-feeding
  • chest pain, fast or irregular heartbeat
  • confusion, restlessness
  • dark yellow or brown urine
  • difficulty breathing or swallowing
  • dizziness or fainting spells
  • drooling, shaking
  • fever, chills, sore throat
  • involuntary or uncontrollable movements of the eyes, mouth, head, arms, and legs
  • seizures
  • stomach area pain
  • unusual bleeding or bruising
  • unusually weak or tired
  • yellowing of skin or eyes

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • difficulty passing urine
  • difficulty sleeping
  • headache
  • sexual dysfunction


Last Updated: May 07, 2013
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